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This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因编码形成核内附着到核孔复合物(NPC的)的内表面的长丝大卷曲螺旋蛋白质。蛋白质直接与NPC的几个组件进行交互。它需要的mRNA和某些蛋白质的核输出。该基因与几种不同的激酶基因的5‘端的致癌融合发生在一些瘤形成。 [由RefSeq的,2008年7月提供]
TPR基因(以及对应的蛋白质)的细胞分布位置:
TPR基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Papillary thyroid carcinoma | 0.120271442 | 1 | 0 | BeFree_ORPHANET |
Thyroid Neoplasm | 0.12 | 1 | 0 | CTD_human |
Ependymoma | 0.00272435 | 1 | 0 | LHGDN |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Charcot-Marie-Tooth Disease | 0.000271442 | 1 | 0 | BeFree |
Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Syphilis | 0.000271442 | 1 | 0 | BeFree |
Metastatic malignant neoplasm to brain | 0.000271442 | 1 | 0 | BeFree |
Spastic syndrome | 0.000271442 | 1 | 0 | BeFree |
Neuropathy | 0.000271442 | 1 | 0 | BeFree |
PITUITARY ADENOMA PREDISPOSITION (disorder) | 0.000271442 | 1 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
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