TOB1(transducer of ERBB2, 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

17q21.33
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

[中文简述(自动翻译):]  这个基因编码erbB-2的/ B细胞易位基因蛋白家族的换能器的部件。这个家庭的成员是具有调节细胞生长的潜在抗增殖因子。所编码的蛋白质可作为肿瘤抑制基因发挥作用。选择性剪接结果在多个抄本变形。 [由RefSeq的，2011年8月提供]

OMIM数据库中对TOB1基因的介绍     Wikipedia数据库中对TOB1基因的介绍

基因序列

基因序列

TOB1基因的碱基序列：[NCBI]

基因突变

基因突变

TOB1基因的碱基突变：           显示全部snp
rs1134637       rs9898809       rs12601477       rs12949115       rs12950561       rs34700818       rs35220381       rs56406873       rs61745076       rs74741906       rs76008726       rs78420930       rs113347817       rs114954245       rs146677221       rs149089074       rs149665551       rs181772626       rs184618775       rs185064946       rs189443964       rs192248010       rs192936305       rs367784153       rs376986962       rs527563391       rs527757415       rs529947216       rs530075293       rs531310206       rs531810177       rs534246569       rs534811510       rs535537421       rs536560118       rs538891756       rs540782672      
rs543734471       rs543758698       rs544688146       rs544726794       rs547443407       rs547604344       rs547698378       rs547736823       rs548711506       rs549494362       rs549959638       rs551903092       rs553013069       rs555249231       rs556311785       rs556472935       rs558147708       rs560729781       rs561318783       rs562291343       rs562753914       rs563623845       rs564516428       rs564555346       rs566688334       rs567331742       rs569325435       rs569878878       rs571544354       rs571670757       rs571942326       rs572064472       rs574151028       rs574213094       rs574375524       rs574619844       rs576256364       rs576712914       rs578092684       rs767085470       rs3316       rs4626       rs1804535       rs7221352       rs8076240       rs9303568       rs9903822       rs11656976       rs61482741       rs61756340       rs71149322       rs78094152       rs78127036       rs79709780       rs111306769       rs112757466       rs115539764       rs117590667       rs138238810       rs138332498       rs139442203       rs139976304       rs140363538       rs141596811       rs142180537       rs142442521       rs143162406       rs143936882       rs144039942       rs147060344       rs147278470       rs147295634       rs147471731       rs147865037       rs148273229       rs148660107       rs148778191       rs149186016       rs150689356       rs151200909       rs151330534       rs181473269       rs182175309       rs182804815       rs182886498       rs183389927       rs186128212       rs186143480       rs186272223       rs189849570       rs190664211       rs191169644       rs199812567       rs199825323       rs199928565       rs199964464       rs200508715       rs200537818       rs200947844       rs201762176       rs201802177       rs202080090       rs369296548       rs369757476       rs370290345       rs371008613       rs371032220       rs371095924       rs371218411       rs372275994       rs372810876       rs372990792       rs374304016       rs375119878       rs376215993       rs376298909       rs377106713       rs377647202       rs528956204       rs528984520       rs531195342       rs531249134       rs532635776       rs533029824       rs533599935       rs536999813       rs537728941       rs537767562       rs538287310       rs540933567       rs541611057       rs541613768       rs541811921       rs543991608       rs544943436       rs546141629       rs546707542       rs548658199       rs548768969       rs551260645       rs552620905       rs552701860       rs552929180       rs553233949       rs553936596       rs554410512       rs555630059       rs557504479       rs557665749       rs560500654       rs561269834       rs563319632       rs564647004       rs566161683       rs566245802       rs566445160       rs566490929       rs568123826       rs571070796       rs571101443       rs572988040       rs572989531       rs573188973       rs575736346       rs578238989       rs745322271       rs745788035       rs746246834       rs746456260       rs746644900       rs746996135       rs747047424       rs747354797       rs747797954       rs747955608       rs748192015       rs748240956       rs748710916       rs748817533       rs749113017       rs749573578       rs750134241       rs750537395       rs750885548       rs751087917       rs751195331       rs751434322       rs751789459       rs752559135       rs752719098       rs752909817       rs753801414       rs753893783       rs754352384       rs754391215       rs754393844       rs754749760       rs754991713       rs755783412       rs755939254       rs756279784       rs756477498       rs756657571       rs756710319       rs756855994       rs757271364       rs757887823       rs758280690       rs758408408       rs758644657       rs759127033       rs759229481       rs759460264       rs759842406       rs760003946       rs760446735       rs760476455       rs761445178       rs761559367       rs761716767       rs762622648       rs762912768       rs763003852       rs763941830       rs763947185       rs764364657       rs764523809       rs764649619       rs764958240       rs765113380       rs765519543       rs765789376       rs766136800       rs766473881       rs766636254       rs767413048       rs767468357       rs767583646       rs768018257       rs768385575       rs769013848       rs769078344       rs769398853       rs769567203       rs769700638       rs770602110       rs770720222       rs770963023       rs771366259       rs771552126       rs772264331       rs772327608       rs772415182       rs772466644       rs773196834       rs773238488       rs773249365       rs773813798       rs773976283       rs774037272       rs774508940       rs774905049       rs775169717       rs775734738       rs775896200       rs775919369       rs776043962       rs776434253       rs776473699       rs776663210       rs777086123       rs777132832       rs777714697       rs777982053       rs778384383       rs778966515       rs779065623       rs779166248       rs779250312       rs779968148       rs780263397       rs780286553       rs780759008       rs780883889       rs781238312       rs781285509      

基因表达

基因表达

TOB1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTCTGTCCTCTGTCCTCAG
59
ATGTTGACACGTCTCCTGG
60
CTCTGTCCTCTGTCCTCAG
59
AAATGTTGACACGTCTCCT
57
CTCTGTCCTCTGTCCTCAG
59
AATGTTGACACGTCTCCTG
58
TGCTACCTGAACAAGATCAC
58
ACTTGGATTTCAAGCTGCA
58
TTGCTACCTGAACAAGATCAC
58
ACTTGGATTTCAAGCTGCA
58
CTCTGTCCTCTGTCCTCAG
59
CTTGAGTGATCTTGTTCGGG
59
CTCTGTCCTCTGTCCTCAG
59
GAGTGATCTTGTTCGGGCT
60
CTCTGTCCTCTGTCCTCAG
59
TTGAGTGATCTTGTTCGGG
58
TGCTACCTGAACAAGATCAC
58
TACTTGGATTTCAAGCTGCA
58

转录因子

转录因子

转录因子
影响类型
PubMed链接
IL2
Repression
11694881

基因本体信息

TOB1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TOB1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003714
P50616(UniProtKB)
IEA
GO:0005070
P50616(UniProtKB)
TAS
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005515
P50616(UniProtKB)
IPI
GO:0005634
P50616(UniProtKB)
IEA
GO:0005737
P50616(UniProtKB)
IEA
GO:0007184
P50616(UniProtKB)
IEA
GO:0008285
P50616(UniProtKB)
IDA
GO:0008285
P50616(UniProtKB)
IDA
GO:0009967
P50616(UniProtKB)
IEA
GO:0017148
P50616(UniProtKB)
IDA
GO:0030014
P50616(UniProtKB)
IDA
GO:0030514
P50616(UniProtKB)
IEA
GO:0030971
P50616(UniProtKB)
IDA
GO:0045668
P50616(UniProtKB)
IEA
GO:0046332
P50616(UniProtKB)
IEA
GO:0060212
P50616(UniProtKB)
IDA
GO:0060213
P50616(UniProtKB)
IDA
GO:1900153
P50616(UniProtKB)
IDA
GO:1903507
P50616(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控TOB1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Endometriosis 0.12 1 0 CTD_human
Neoplasms, Experimental 0.12 1 0 CTD_human
Chloracne 0.12 1 0 CTD_human
Lung Neoplasms 0.00272435 1 0 LHGDN
Malignant neoplasm of stomach 0.001085767 4 0 BeFree
Neoplasm Metastasis 0.001085767 4 0 BeFree
Stomach Carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Experimental Autoimmune Encephalomyelitis 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Chondrosarcoma 0.000271442 1 0 BeFree
Demyelinating Diseases 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Mammary Neoplasms 0.000271442 1 0 BeFree
Clinically isolated syndrome 0.000271442 1 0 BeFree

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