更多...
收起
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  呼吸链,这是专门涉及琥珀酸的氧化复合物II,进行电子从FADH到辅酶Q。复杂的是由四核编码亚基在线粒体内膜进行本地化。铁硫亚基是高度保守的并包含三个富含半胱氨酸的簇可以包括酶的铁硫中心。在该基因导致副神经节瘤和嗜铬细胞瘤散发性和家族的突变,并支持??线粒体功能障碍和肿瘤发生之间的联系。 [由RefSeq的,2008年7月提供]
SDHB基因(以及对应的蛋白质)的细胞分布位置:
SDHB基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Pheochromocytoma | 0.429028364 | 91 | 10 | BeFree_CLINVAR_CTD_human_GAD_LHGDN_UNIPROT |
PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA | 0.361628651 | 6 | 0 | BeFree_CLINVAR_CTD_human_ORPHANET |
PARAGANGLIOMAS 4 | 0.36 | 5 | 9 | CLINVAR_CTD_human_UNIPROT |
Gastrointestinal Stromal Tumors | 0.249510397 | 26 | 3 | BeFree_CLINVAR_LHGDN_ORPHANET |
Paraganglioma | 0.2114122 | 127 | 0 | BeFree_CTD_human_GAD_LHGDN |
Hamartoma Syndrome, Multiple | 0.123724241 | 5 | 0 | BeFree_GAD_ORPHANET |
Carney Triad | 0.121085767 | 4 | 1 | BeFree_CLINVAR |
Mitochondrial Complex II Deficiency | 0.120814326 | 3 | 0 | BeFree_ORPHANET |
Neoplastic Syndromes, Hereditary | 0.12 | 0 | 31 | CLINVAR |
Hereditary Paraganglioma-Pheochromocytoma Syndrome | 0.12 | 0 | 6 | CLINVAR |
COWDEN-LIKE SYNDROME (disorder) | 0.12 | 0 | 0 | CTD_human |
COWDEN SYNDROME 2 | 0.12 | 0 | 2 | CLINVAR |
Adrenal Gland Neoplasms | 0.028947267 | 14 | 0 | BeFree_GAD |
Renal Cell Carcinoma | 0.0112586 | 15 | 0 | BeFree_GAD_LHGDN |
Paragangliomas, head and neck | 0.007719925 | 13 | 0 | BeFree_GAD |
Head and Neck Neoplasms | 0.007101096 | 3 | 0 | GAD |
Kidney Neoplasm | 0.006448592 | 7 | 0 | BeFree_GAD_LHGDN |
Von Hippel-Lindau Syndrome | 0.005352893 | 12 | 0 | BeFree_GAD |
Hereditary Paraganglioma | 0.004071628 | 15 | 0 | BeFree |
Multiple Endocrine Neoplasia Type 2a | 0.003452799 | 5 | 0 | BeFree_GAD |
Thyroid carcinoma | 0.003181358 | 4 | 0 | BeFree_GAD |
Narcolepsy | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Multiple Primary | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Hypoxia | 0.002367032 | 1 | 0 | GAD |
Cancer of Head and Neck | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of prostate | 0.002367032 | 1 | 0 | GAD |
Neurofibromatosis 1 | 0.002171535 | 8 | 0 | BeFree |
Carcinogenesis | 0.002171535 | 8 | 0 | BeFree |
Neoplasm Metastasis | 0.001900093 | 7 | 0 | BeFree |
Carotid Body Paraganglioma | 0.001628651 | 6 | 0 | BeFree |
Neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of kidney | 0.001357209 | 5 | 0 | BeFree |
Pheochromocytoma, Extra-Adrenal | 0.001357209 | 5 | 0 | BeFree |
Extra-Adrenal Paraganglioma | 0.001085767 | 4 | 0 | BeFree |
Pituitary Diseases | 0.001085767 | 4 | 0 | BeFree |
Pheochromocytoma, malignant | 0.001085767 | 4 | 0 | BeFree |
Central neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Renal carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant Paraganglionic Neoplasm | 0.001085767 | 4 | 1 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Diabetic Retinopathy | 0.000814326 | 3 | 0 | BeFree |
Leukodystrophy | 0.000814326 | 3 | 0 | BeFree |
Multiple Endocrine Neoplasia | 0.000814326 | 3 | 0 | BeFree |
metastatic pheochromocytoma | 0.000814326 | 3 | 0 | BeFree |
Dissecting aneurysm of the thoracic aorta | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000542884 | 2 | 0 | BeFree |
Hypertensive disease | 0.000542884 | 2 | 0 | BeFree |
Pituitary Adenoma | 0.000542884 | 2 | 0 | BeFree |
Multiple tumors | 0.000542884 | 2 | 0 | BeFree |
Succinate-coenzyme Q reductase deficiency | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Mitochondrial Diseases | 0.000542884 | 2 | 0 | BeFree |
Cardiomyopathies | 0.000542884 | 2 | 3 | BeFree |
Gastric Gastrointestinal Stromal Tumor | 0.000542884 | 2 | 0 | BeFree |
Bilateral pheochromocytoma and islet cell adenoma of the pancreas | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Phyllodes Tumor | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Glomus Tumor | 0.000271442 | 1 | 0 | BeFree |
Heart Neoplasm | 0.000271442 | 1 | 1 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Hypertensive crisis | 0.000271442 | 1 | 0 | BeFree |
Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Muscle hypotonia | 0.000271442 | 1 | 3 | BeFree |
Prolactinoma | 0.000271442 | 1 | 0 | BeFree |
Thoracic Outlet Syndrome | 0.000271442 | 1 | 0 | BeFree |
Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
Benign Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Proliferative diabetic retinopathy | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma, Oxyphilic | 0.000271442 | 1 | 0 | BeFree |
Neuroendocrine Tumors | 0.000271442 | 1 | 0 | BeFree |
Systolic hypertension | 0.000271442 | 1 | 0 | BeFree |
Diastolic hypertension | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Leukoencephalopathies | 0.000271442 | 1 | 0 | BeFree |
Sympathetic paraganglioma | 0.000271442 | 1 | 0 | BeFree |
Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Collecting Duct Carcinoma of the Kidney | 0.000271442 | 1 | 0 | BeFree |
Bladder Paraganglioma | 0.000271442 | 1 | 0 | BeFree |
Mesenchymal Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Well Differentiated Pancreatic Endocrine Tumor | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Hereditary Leiomyomatosis and Renal Cell Cancer | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Clear-cell metastatic renal cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。