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This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]
[中文简述(自动翻译):]  这个基因编码磷脂酰肌醇(PI)的4-激酶,其催化在磷酸肌醇-4,5-二磷酸的生物合成的第一个关键步骤。哺乳动物PI 4-激酶已被分为两种类型,II和III,是根据它们的分子质量,并且通过洗涤剂和腺苷调制。由该基因编码的蛋白质是III型酶不是由腺苷抑制。 [由RefSeq的,2014年9月提供]
PI4KA基因(以及对应的蛋白质)的细胞分布位置:
PI4KA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Schizophrenia | 0.005819831 | 4 | 2 | BeFree_GAD |
Bipolar Disorder | 0.002367032 | 1 | 0 | GAD |
Amphetamine-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Hepatitis C | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
DiGeorge Syndrome | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Shprintzen syndrome | 0.000271442 | 1 | 0 | BeFree |
Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
22q11 partial monosomy syndrome | 0.000271442 | 1 | 0 | BeFree |
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