更多...
收起
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
[中文简述(自动翻译):]  此基因编码起着先天和适应性免疫反应的中心作用胞质衔接蛋白。这种蛋白质的功能如白介素-1和Toll样受体信号途径的重要信号转导。这些途径调节促炎众多基因的活化。所编码的蛋白质包括一个N-末端的死亡结构域和C-末端电话-白细胞介受体结构域的。患者在该基因的缺陷有增加的易感性化脓性细菌感染。选择性剪接结果在多个抄本变形。 [由RefSeq的,2010年2月提供]
MYD88基因(以及对应的蛋白质)的细胞分布位置:
MYD88基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
MYD88 Deficiency | 0.480542884 | 3 | 2 | BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT |
Waldenstrom Macroglobulinemia | 0.129229024 | 34 | 3 | BeFree_ORPHANET |
Diffuse Large B-Cell Lymphoma | 0.122171535 | 9 | 1 | BeFree_CTD_human |
Neoplastic Cell Transformation | 0.12 | 1 | 0 | CTD_human |
Inflammation | 0.12 | 1 | 0 | CTD_human |
Lymphoma, Follicular | 0.12 | 1 | 0 | CTD_human |
Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
Reperfusion Injury | 0.12 | 1 | 0 | CTD_human |
Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Lymphoma | 0.00643866 | 15 | 1 | BeFree_GAD |
Bacterial Infections | 0.005710211 | 12 | 0 | BeFree_LHGDN |
Sepsis | 0.003995683 | 7 | 0 | BeFree_GAD |
Chronic Lymphocytic Leukemia | 0.003257302 | 12 | 1 | BeFree |
ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Malignant lymphoma - lymphoplasmacytic | 0.002714419 | 10 | 1 | BeFree |
Rheumatoid Arthritis | 0.002638474 | 2 | 1 | BeFree_GAD |
Lupus Erythematosus, Systemic | 0.002638474 | 2 | 0 | BeFree_GAD |
Urinary tract infection | 0.002638474 | 2 | 0 | BeFree_GAD |
Coronary heart disease | 0.002367032 | 1 | 0 | GAD |
Cystitis | 0.002367032 | 1 | 0 | GAD |
Hepatitis C | 0.002367032 | 1 | 0 | GAD |
Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Pyelonephritis | 0.002367032 | 1 | 0 | GAD |
Colitis | 0.001900093 | 7 | 0 | BeFree |
Ovarian Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Carcinogenesis | 0.001900093 | 7 | 0 | BeFree |
Malignant neoplasm of ovary | 0.001900093 | 7 | 0 | BeFree |
Lymphoproliferative Disorders | 0.001628651 | 6 | 1 | BeFree |
Septicemia | 0.001628651 | 6 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.001628651 | 6 | 1 | BeFree |
Marginal Zone B-Cell Lymphoma | 0.001628651 | 6 | 1 | BeFree |
Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
B-Cell Lymphomas | 0.001357209 | 5 | 1 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Colorectal Carcinoma | 0.001085767 | 4 | 1 | BeFree |
Multiple Myeloma | 0.001085767 | 4 | 1 | BeFree |
Virus Diseases | 0.001085767 | 4 | 0 | BeFree |
Colorectal Cancer | 0.001085767 | 4 | 1 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Celiac Disease | 0.000814326 | 3 | 0 | BeFree |
Ulcerative Colitis | 0.000814326 | 3 | 1 | BeFree |
HIV Infections | 0.000814326 | 3 | 0 | BeFree |
Ischemia | 0.000814326 | 3 | 0 | BeFree |
Monoclonal Gammopathy of Undetermined Significance | 0.000814326 | 3 | 1 | BeFree |
Mycoses | 0.000814326 | 3 | 0 | BeFree |
Obesity | 0.000814326 | 3 | 0 | BeFree |
Pneumonia | 0.000814326 | 3 | 0 | BeFree |
Tuberculosis | 0.000814326 | 3 | 0 | BeFree |
Splenic Marginal Zone B-Cell Lymphoma | 0.000814326 | 3 | 1 | BeFree |
Hematologic Neoplasms | 0.000814326 | 3 | 1 | BeFree |
Epithelial ovarian cancer | 0.000814326 | 3 | 0 | BeFree |
Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Asthma | 0.000542884 | 2 | 0 | BeFree |
Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Glomerulonephritis | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
Respiratory Syncytial Virus Infections | 0.000542884 | 2 | 0 | BeFree |
Chagas Disease | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Pelvic Inflammatory Disease | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Activated B-Cell-Like Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 1 | BeFree |
Abscess | 0.000271442 | 1 | 0 | BeFree |
Angina, Unstable | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Pneumonia, Bacterial | 0.000271442 | 1 | 0 | BeFree |
Brain Abscess | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Central Nervous System Infection | 0.000271442 | 1 | 0 | BeFree |
Chlamydia Infections | 0.000271442 | 1 | 0 | BeFree |
Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Dental caries | 0.000271442 | 1 | 0 | BeFree |
Dermatitis | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Endophthalmitis | 0.000271442 | 1 | 0 | BeFree |
IGA Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Heart Diseases | 0.000271442 | 1 | 0 | BeFree |
Hemorrhagic Fevers, Viral | 0.000271442 | 1 | 0 | BeFree |
Histiocytosis, Langerhans-Cell | 0.000271442 | 1 | 0 | BeFree |
Hypercholesterolemia | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Influenza | 0.000271442 | 1 | 0 | BeFree |
Keratitis | 0.000271442 | 1 | 0 | BeFree |
Klebsiella Infections | 0.000271442 | 1 | 0 | BeFree |
Leishmaniasis, Visceral | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 1 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Lymphocytosis | 0.000271442 | 1 | 1 | BeFree |
Malaria | 0.000271442 | 1 | 0 | BeFree |
Measles | 0.000271442 | 1 | 0 | BeFree |
Meningitis | 0.000271442 | 1 | 0 | BeFree |
Mycobacterium Infections | 0.000271442 | 1 | 0 | BeFree |
Myositis | 0.000271442 | 1 | 0 | BeFree |
Nephritis | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Pancreatitis | 0.000271442 | 1 | 0 | BeFree |
Paraproteinemias | 0.000271442 | 1 | 1 | BeFree |
Peritonitis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Emphysema | 0.000271442 | 1 | 0 | BeFree |
Rotavirus Infections | 0.000271442 | 1 | 0 | BeFree |
Salmonella infections | 0.000271442 | 1 | 0 | BeFree |
Staphylococcal Skin Infections | 0.000271442 | 1 | 0 | BeFree |
Takayasu Arteritis | 0.000271442 | 1 | 0 | BeFree |
Thromboangiitis Obliterans | 0.000271442 | 1 | 0 | BeFree |
Thymoma | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis, Pulmonary | 0.000271442 | 1 | 2 | BeFree |
Uveitis | 0.000271442 | 1 | 0 | BeFree |
Gram-Positive Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
Soft Tissue Infections | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of rectum | 0.000271442 | 1 | 0 | BeFree |
Acute myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis of aorta | 0.000271442 | 1 | 0 | BeFree |
Cold Hemagglutinin Disease | 0.000271442 | 1 | 0 | BeFree |
Embryonal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hyperviscosity syndrome | 0.000271442 | 1 | 1 | BeFree |
Coronary Stenosis | 0.000271442 | 1 | 0 | BeFree |
Parasitemia | 0.000271442 | 1 | 0 | BeFree |
Bing-Neel syndrome | 0.000271442 | 1 | 1 | BeFree |
Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
Myelokathexis | 0.000271442 | 1 | 1 | BeFree |
Coinfection | 0.000271442 | 1 | 0 | BeFree |
Rhinovirus infection | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Primary central nervous system lymphoma | 0.000271442 | 1 | 0 | BeFree |
Disease caused by Shigella dysenteriae | 0.000271442 | 1 | 0 | BeFree |
Tumor necrosis | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Thyroid associated opthalmopathies | 0.000271442 | 1 | 0 | BeFree |
Stable angina | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Primary immune deficiency disorder | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Trisomy 12 | 0.000271442 | 1 | 0 | BeFree |
Low grade B-cell lymphoma | 0.000271442 | 1 | 1 | BeFree |
WHIM syndrome | 0.000271442 | 1 | 1 | BeFree |
Necrotizing Enterocolitis | 0.000271442 | 1 | 0 | BeFree |
Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 1 | BeFree |
Monocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Viral respiratory infection | 0.000271442 | 1 | 0 | BeFree |
5q-syndrome | 0.000271442 | 1 | 0 | BeFree |
Frontotemporal Lobar Degeneration | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori infection | 0.000271442 | 1 | 0 | BeFree |
Candidemia | 0.000271442 | 1 | 0 | BeFree |
Renal ischaemia | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Collagen-Induced | 0.000271442 | 1 | 0 | BeFree |
Monoclonal Gammapathies | 0.000271442 | 1 | 1 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Cutaneous lymphoma | 0.000271442 | 1 | 1 | BeFree |
Myelodysplastic Syndrome with Isolated del(5q) | 0.000271442 | 1 | 0 | BeFree |
Dysplasia of colon | 0.000271442 | 1 | 0 | BeFree |
M5b Acute differentiated monocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Chronic Q Fever | 0.000271442 | 1 | 1 | BeFree |
Neurological ventriculitis | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Cerebral abscess | 0.000271442 | 1 | 0 | BeFree |
Chromosome 5, trisomy 5q | 0.000271442 | 1 | 0 | BeFree |
IRAK4 Deficiency | 0.000271442 | 1 | 0 | BeFree |
Recurrent bacterial infection | 0.000271442 | 1 | 0 | BeFree |
Hypotrichosis simplex | 0.000271442 | 1 | 0 | BeFree |
Cryopyrin-Associated Periodic Syndromes | 0.000271442 | 1 | 0 | BeFree |
Limb ischemia | 0.000271442 | 1 | 0 | BeFree |
Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。