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This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码线粒体转录终止因子。这种蛋白参与衰减从线粒体基因组的转录;这种衰减允许更高水平的16S核糖体RNA相对于下游的tRNA基因的表达。该基因的产物具有由被所有必需的DNA结合两个基本域括号内的3亮氨酸拉链基序。有证据表明,这种蛋白质,该拉链参与该建立DNA结合所需的三维结构的分子内相互作用。 [由RefSeq的,2008年7月提供]
MTERF1基因(以及对应的蛋白质)的细胞分布位置:
MTERF1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
MELAS Syndrome | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Mitochondrial Diseases | 0.000271442 | 1 | 0 | BeFree |
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