LYZ(lysozyme)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

12q15
基因染色体位置图

基因简述

基因简述

This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

[中文简述(自动翻译):]  这个基因编码人溶菌酶，其天然底物是细菌细胞壁的肽聚糖（裂解的测试[1-4] N-乙酰胞壁酸和N-乙酰葡糖胺之间的糖苷键）。溶菌酶是在人乳中发现的抗微生物剂中的一个，并且也存在于脾，肺，肾，白血细胞，血浆，唾液和眼泪。该蛋白质具有对许多细菌种类的抗菌活性。在该基因的错义突变已经在遗传肾淀粉样变被确定。 [由RefSeq的，2014年10月提供]

OMIM数据库中对LYZ基因的介绍     Wikipedia数据库中对LYZ基因的介绍

基因序列

基因序列

LYZ基因的碱基序列：[NCBI]

基因突变

基因突变

LYZ基因的碱基突变：           显示全部snp
rs1384       rs8612       rs10049       rs483142       rs511589       rs513342       rs544471       rs547332       rs593343       rs596526       rs596919       rs613782       rs639318       rs686407       rs710794       rs777262       rs777263       rs1800973       rs3206308       rs4761155       rs7961618       rs7969127       rs7970329       rs10878967       rs11177605       rs11177606       rs11177607       rs12300418       rs12310080       rs12313465       rs12368207       rs12812860       rs17426159       rs34540118       rs35913784       rs56792375       rs57954211      
rs61576454       rs71094709       rs73145933       rs73151633       rs74736576       rs75846229       rs77627949       rs77814357       rs77917676       rs77970934       rs79455410       rs80276735       rs111402206       rs111599152       rs111690244       rs112295070       rs112616535       rs113428994       rs113581136       rs113933446       rs114749447       rs116286017       rs138672030       rs139000773       rs139882444       rs140806935       rs141295355       rs141911537       rs143566752       rs143871171       rs143883804       rs144355664       rs147465274       rs147486052       rs148563311       rs148802204       rs148899470       rs150612478       rs150655870       rs151295956       rs181359106       rs181401096       rs181603057       rs181795824       rs182116777       rs182362151       rs182995763       rs183375295       rs183441118       rs183616345       rs183654112       rs184755234       rs185356402       rs185464451       rs185823653       rs186672293       rs186983617       rs187137839       rs187254869       rs187557119       rs188271229       rs188313797       rs188512539       rs188841679       rs188895813       rs189421061       rs190119614       rs190229481       rs190387315       rs190447782       rs190909207       rs191625514       rs191962488       rs193040437       rs193056383       rs199649408       rs200491782       rs200770300       rs367623154       rs367682582       rs367941288       rs367987339       rs370104879       rs370786680       rs372724691       rs373108192       rs373236111       rs373332187       rs373366975       rs374024821       rs374368794       rs374391788       rs374990260       rs375298132       rs376558181       rs377063961       rs377318354       rs528547245       rs528702784       rs528865464       rs528901818       rs529716080       rs530096985       rs531119114       rs531184978       rs531216297       rs531233279       rs531261534       rs531950211       rs532333761       rs532359992       rs532805694       rs534565279       rs536078811       rs536843528       rs536905143       rs537478232       rs537501594       rs538672759       rs538701737       rs539317291       rs539633969       rs539909192       rs540508585       rs540509233       rs540772171       rs540927027       rs541086561       rs543244708       rs544272676       rs544436978       rs545064117       rs545469173       rs545497786       rs546020417       rs546257742       rs546797818       rs547408249       rs547927153       rs547956404       rs548282749       rs548340567       rs549022816       rs549484204       rs549646099       rs550189893       rs550470703       rs550843763       rs551709281       rs552050041       rs552111542       rs552815022       rs553286426       rs553775122       rs557112167       rs557612393       rs557655266       rs558145886       rs558808847       rs558845830       rs559260409       rs559988516       rs560228565       rs560424596       rs561316919       rs561471991       rs561500996       rs561527308       rs561564291       rs562510934       rs562672042       rs562830363       rs563837795       rs563901050       rs565084636       rs565097220       rs565177440       rs566395762       rs566937585       rs567490069       rs567541896       rs567789310       rs568058282       rs568773222       rs569016459       rs570121782       rs570266212       rs570301202       rs571437062       rs571477475       rs571562680       rs571592135       rs572331611       rs573253660       rs573367009       rs573507892       rs574091679       rs574532858       rs574722747       rs574791821       rs574991035       rs575329707       rs575850148       rs576522577       rs577002650       rs577040070       rs577697172       rs745417952       rs745834052       rs746015240       rs746549210       rs746892642       rs747456695       rs747686102       rs748397486       rs748534575       rs748810774       rs749469402       rs749506970       rs750094984       rs750113375       rs750310489       rs751118616       rs751442626       rs751472787       rs751921161       rs752105833       rs752123879       rs753155051       rs753567842       rs753903743       rs754436138       rs754903326       rs755306264       rs755360267       rs756637007       rs756931248       rs757488716       rs757542803       rs757720885       rs757816962       rs757850838       rs757910877       rs758762911       rs758850988       rs759386795       rs759470900       rs759489268       rs759506432       rs760040859       rs760486480       rs760760746       rs761096773       rs761196412       rs761441045       rs761723823       rs761943523       rs762050850       rs762497316       rs762616173       rs762738984       rs764263034       rs764483042       rs765231566       rs765265338       rs765836787       rs766102897       rs766207206       rs766311307       rs766880379       rs767355785       rs767804731       rs767865867       rs767995176       rs768344995       rs768493503       rs769164902       rs769357949       rs769954942       rs770053001       rs770565428       rs770942584       rs771044104       rs771751599       rs771942161       rs772016638       rs772270511       rs773204148       rs773233570       rs774421958       rs774434533       rs774734206       rs775474378       rs776078771       rs776141573       rs776243268       rs776358238       rs776718571       rs776898103       rs777014130       rs777499003       rs778410659       rs778519129       rs778931771       rs779554998       rs779641708       rs779922074       rs780222361       rs780885825       rs781073990       rs781174522       rs781538176       rs781727930      

基因表达

基因表达

LYZ基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGCAAACTGGATGTGTTTGG
59
TCAGTGCTTCTGTCTCCAG
59
TTGAAAGGTGTGAGTTGGC
59
AACACATCCAGTTTGCTAGG
58
TTGAAAGGTGTGAGTTGGC
59
AAACACATCCAGTTTGCTAGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LYZ基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

LYZ基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003796
A0A0B4J259(UniProtKB)
IEA
GO:0003796
F8VV32(UniProtKB)
IEA
GO:0001895
P61626(UniProtKB)
IEP
GO:0003796
P61626(UniProtKB)
TAS
GO:0005576
P61626(UniProtKB)
TAS
GO:0005576
P61626(UniProtKB)
TAS
GO:0005615
P61626(UniProtKB)
IDA
GO:0005615
P61626(UniProtKB)
IDA
GO:0005615
P61626(UniProtKB)
IDA
GO:0005615
P61626(UniProtKB)
TAS
GO:0006954
P61626(UniProtKB)
TAS
GO:0019835
P61626(UniProtKB)
IEA
GO:0042742
P61626(UniProtKB)
IEA
GO:0042802
P61626(UniProtKB)
IPI
GO:0044267
P61626(UniProtKB)
TAS
GO:0070062
P61626(UniProtKB)
IDA
GO:0070062
P61626(UniProtKB)
IDA
GO:0070062
P61626(UniProtKB)
IDA
GO:0070062
P61626(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控LYZ基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Amyloidosis, familial visceral 0.36 1 4 CLINVAR_CTD_human_UNIPROT
Amyloidosis 0.005981653 13 0 BeFree_LHGDN
Leukemia, Myelocytic, Acute 0.003538676 4 0 BeFree_LHGDN
Hypertensive disease 0.00272435 1 0 LHGDN
Chorioamnionitis 0.002367032 1 0 GAD
Fetal Membranes, Premature Rupture 0.002367032 1 0 GAD
Premature Obstetric Labor 0.002367032 1 0 GAD
Pre-Eclampsia 0.002367032 1 0 GAD
Premature Birth 0.002367032 1 0 GAD
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified 0.002367032 1 0 GAD
Systemic amyloidosis 0.002171535 8 1 BeFree
Primary Systemic Amyloidosis 0.002171535 8 1 BeFree
Crohn Disease 0.001085767 4 0 BeFree
Kidney Diseases 0.000814326 3 0 BeFree
Amyloid nephropathy 0.000814326 3 0 BeFree
Plaque, Amyloid 0.000814326 3 1 BeFree
Ulcerative Colitis 0.000542884 2 0 BeFree
Craniosynostosis 0.000542884 2 0 BeFree
Diarrhea 0.000542884 2 0 BeFree
Inflammatory Bowel Diseases 0.000542884 2 0 BeFree
Malignant neoplasm of stomach 0.000542884 2 0 BeFree
Familial Mediterranean Fever 0.000542884 2 0 BeFree
Tuberculosis 0.000542884 2 0 BeFree
Chronic sinusitis 0.000542884 2 0 BeFree
Amyloidosis, Hereditary 0.000542884 2 1 BeFree
Familial Amyloid Neuropathy, Portuguese Type 0.000542884 2 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Adenoma 0.000271442 1 0 BeFree
Alzheimer's Disease 0.000271442 1 0 BeFree
Anemia, Sickle Cell 0.000271442 1 0 BeFree
Arteriosclerosis 0.000271442 1 0 BeFree
Arthritis 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Atherosclerosis 0.000271442 1 0 BeFree
Bacterial Infections 0.000271442 1 0 BeFree
Celiac Disease 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Shigella Infections 0.000271442 1 0 BeFree
Gastritis 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Hay fever 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
Hyperlipidemia 0.000271442 1 0 BeFree
Liver diseases 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Lymphoma 0.000271442 1 0 BeFree
Mycoses 0.000271442 1 0 BeFree
Paratuberculosis 0.000271442 1 0 BeFree
Petechiae 0.000271442 1 0 BeFree
Adenomatous Polyposis Coli 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Skin lesion 0.000271442 1 0 BeFree
Tuberculosis, Pulmonary 0.000271442 1 0 BeFree
Vitamin A Deficiency 0.000271442 1 0 BeFree
Cataract 0.000271442 1 0 BeFree
Sicca Syndrome 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Amyloid Neuropathies, Familial 0.000271442 1 0 BeFree
Acinar Cell Carcinoma 0.000271442 1 0 BeFree
Abdominal discomfort 0.000271442 1 0 BeFree
Chronic abdominal pain 0.000271442 1 0 BeFree
Gastrointestinal Stromal Tumors 0.000271442 1 0 BeFree
Renal glomerular disease 0.000271442 1 0 BeFree
Gastrointestinal symptom 0.000271442 1 0 BeFree
invasive cancer 0.000271442 1 0 BeFree
Pseudomonas aeruginosa infection 0.000271442 1 0 BeFree
Infectious disease of lung 0.000271442 1 0 BeFree
Vascular inflammations 0.000271442 1 0 BeFree
Follicular bronchiolitis 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree

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