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This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的赖氨酰氧化酶基因家族的一个成员。该家族的原型成员是结缔组织的生物合成必需的,编码胞外铜 - 依赖性胺氧化酶催化,在胶原和弹性蛋白的形成交联的第一个步骤。在C末端端部的高度保守的氨基酸序列显示为足以胺氧化酶的活性,这表明每个家庭成员可以保留该功能。 N末端是保守性差,可能传授发育调控,衰老,抑制肿瘤细胞的生长控制和趋化其他角色家庭的每个成员。可选地,该基因的剪接转录变异体已被报道,但其全长性质尚未确定。 [由RefSeq的,2008年7月提供]
LOXL3基因(以及对应的蛋白质)的细胞分布位置:
LOXL3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Intracranial Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Stickler syndrome (disorder) | 0.000271442 | 1 | 0 | BeFree |
Vascular lesions | 0.000271442 | 1 | 0 | BeFree |
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