HLA-DQA2(major histocompatibility complex, class II, DQ alpha 2) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

6p21.3
基因染色体位置图

基因简述

基因简述

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]

[中文简述(自动翻译):]  

OMIM数据库中对HLA-DQA2基因的介绍     Wikipedia数据库中对HLA-DQA2基因的介绍

基因序列

基因序列

HLA-DQA2基因的碱基序列：[NCBI]

基因突变

基因突变

HLA-DQA2基因的碱基突变：           显示全部snp
rs1744       rs1129956       rs2051597       rs2051598       rs2051599       rs2051600       rs2071798       rs2071799       rs2071800       rs2213565       rs2213567       rs2213568       rs2227127       rs2227128       rs2239799       rs2239800       rs2395249       rs2395250       rs2395251       rs2395252       rs2395253       rs2894287       rs2894288       rs2894289       rs2894290       rs3040582       rs3208181       rs4394270       rs4398729       rs4403295       rs4452680       rs4455709       rs4496840       rs5018343       rs5021448       rs5021449       rs5021450      
rs5021452       rs5021453       rs5875400       rs5875402       rs6457645       rs6907815       rs6908052       rs6919691       rs7450522       rs7755792       rs7771968       rs9272945       rs9276368       rs9276369       rs9276370       rs9276373       rs9276375       rs9276376       rs9276377       rs9276378       rs9276379       rs9276381       rs9276382       rs9276383       rs9276385       rs9276389       rs9276390       rs9276391       rs9276392       rs9276393       rs9276394       rs9276395       rs9276396       rs9276397       rs9276398       rs9276399       rs9276400       rs9276401       rs9276402       rs9276403       rs9276407       rs9276408       rs9276409       rs9276410       rs9276411       rs9276412       rs9276413       rs9276414       rs9276415       rs9276416       rs9276417       rs9276418       rs9276419       rs9276420       rs9276421       rs9276422       rs9276423       rs9276424       rs9276425       rs9276426       rs9276427       rs9276428       rs9276429       rs9276430       rs9276431       rs9276432       rs9276433       rs9276434       rs9276435       rs9276436       rs9276437       rs9276438       rs9276439       rs9276440       rs9276441       rs9276442       rs9276443       rs9282267       rs9282269       rs9368740       rs9461806       rs9469263       rs9469264       rs9469266       rs9717634       rs10947337       rs10947338       rs16870693       rs17213281       rs17213337       rs17213351       rs17219750       rs17432921       rs17500468       rs17500482       rs17500510       rs28371351       rs28371352       rs28371353       rs28371354       rs28371355       rs28406286       rs28420297       rs28421301       rs28459946       rs28459982       rs28577241       rs28666756       rs28810210       rs28817596       rs28857832       rs28993557       rs34023144       rs34292908       rs34309530       rs34355847       rs34357612       rs34688787       rs34730447       rs34836624       rs35121587       rs35159398       rs35207778       rs35368813       rs35603647       rs35995584       rs41288889       rs57007283       rs59593022       rs60561792       rs61363242       rs62619945       rs62623408       rs68002097       rs71536152       rs71536153       rs73400718       rs73400748       rs73400749       rs73400755       rs74223470       rs75108103       rs75289558       rs75823430       rs76818120       rs76846991       rs77766348       rs78163898       rs78366910       rs79017203       rs79517313       rs79816623       rs112238184       rs112333001       rs112340397       rs112345140       rs112411851       rs112501123       rs112600646       rs112651943       rs112671150       rs113156102       rs113435733       rs113998262       rs114106517       rs114155046       rs114273397       rs114318456       rs115018313       rs115121776       rs115326848       rs115355381       rs115544552       rs116076279       rs116163401       rs116257678       rs116570528       rs116659129       rs116714440       rs116727032       rs117094765       rs117150626       rs117160199       rs117358580       rs117489278       rs117610182       rs117615570       rs117735661       rs117849668       rs118173848       rs138296677       rs138695970       rs139676082       rs139751194       rs139841858       rs139984589       rs140710949       rs140747500       rs141261176       rs141270733       rs141350816       rs141446522       rs141741917       rs142101038       rs142153577       rs142826528       rs142901825       rs142926877       rs142944862       rs143201195       rs143598254       rs144060347       rs144194251       rs144953122       rs145055982       rs145449397       rs145534584       rs145628230       rs145976370       rs146057838       rs146449814       rs146579631       rs146594639       rs146924711       rs147402945       rs147432782       rs147541411       rs147801222       rs148257063       rs148264270       rs148573253       rs148720159       rs148839152       rs148982386       rs149033708       rs149355435       rs149491519       rs149600768       rs150571063       rs150813279       rs180819549       rs180964265       rs181327943       rs182157803       rs183787735       rs185088560       rs185422719       rs186430666       rs186853831       rs186864820       rs186999302       rs188034073       rs188057497       rs188385659       rs189471810       rs191050718       rs191390327       rs191520528       rs199602635       rs199605299       rs199612824       rs199931222       rs200008630       rs200117788       rs200214008       rs200236721       rs200493696       rs200495415       rs200745258       rs200799307       rs200904145       rs200936222       rs200986700       rs201069397       rs201291459       rs201688857       rs201776159       rs201822870       rs201835063       rs201984640       rs202183183       rs368105988       rs369556704       rs371043199       rs371762156       rs371768133       rs371900898       rs372036201       rs372706143       rs372730029       rs374527586       rs375166343       rs375416271       rs376688011       rs376884092       rs377317282       rs377334324       rs377499056       rs527908650       rs528169683       rs528205367       rs528542896       rs528979518       rs530043660       rs530133093       rs531407930       rs531697297       rs532057622       rs532501676       rs533576674       rs534156426       rs534494500       rs535638659       rs535881482       rs536124194       rs537289685       rs537930464       rs538929760       rs539215922       rs539796289       rs539880570       rs540111708       rs540118474       rs540706521       rs542967449       rs543040210       rs543816417       rs544237085       rs545578631       rs546146998       rs546150035       rs546261104       rs546312593       rs546632638       rs546688276       rs547577107       rs548161460       rs548408982       rs549012799       rs549100123       rs549328576       rs549426719       rs549713408       rs549720584       rs549884406       rs551199128       rs551835186       rs551875727       rs551926143       rs552052007       rs553147850       rs554132108       rs555605406       rs555793877       rs555835513       rs556206852       rs557319171       rs557386636       rs557518685       rs557518705       rs557893164       rs558284633       rs558440406       rs558762403       rs559479528       rs559584379       rs559728393       rs560648126       rs561341145       rs561598260       rs561617544       rs561828705       rs562134128       rs563371037       rs563409640       rs563488460       rs563658629       rs563737267       rs563775447       rs564004411       rs564180434       rs565947970       rs566459845       rs566889713       rs567599320       rs567649680       rs567793498       rs568726968       rs569618879       rs570165764       rs570253289       rs572758897       rs573109172       rs573580167       rs574010716       rs574225904       rs574515192       rs574670717       rs575035503       rs575178386       rs575418310       rs576049943       rs745328209       rs745818601       rs745921328       rs746116777       rs746413309       rs746449452       rs747090472       rs747567799       rs747575164       rs747825464       rs747884693       rs748083412       rs748134489       rs748352566       rs748886224       rs749049122       rs749325561       rs749505656       rs749681392       rs750124538       rs750346942       rs750591825       rs750646643       rs751204420       rs751979111       rs752032457       rs752032531       rs752083762       rs752313403       rs752554226       rs752841211       rs753047799       rs753137613       rs753327859       rs753334585       rs753741611       rs753775780       rs753792504       rs753973878       rs754108851       rs754332079       rs754448406       rs754460344       rs755033490       rs755273163       rs755314566       rs755397266       rs755624302       rs755856546       rs755904278       rs756475269       rs756707474       rs756739723       rs757207299       rs757340022       rs757362505       rs758157631       rs758180668       rs758244642       rs758449250       rs758485154       rs758626812       rs758961074       rs759132441       rs759459560       rs759547222       rs759867377       rs760001092       rs760253801       rs760742525       rs760855083       rs760958697       rs761057020       rs761107967       rs761395556       rs762000295       rs762074519       rs762181278       rs762184714       rs762317175       rs762568360       rs762990424       rs763073248       rs763203240       rs763255147       rs764219991       rs764361665       rs764439734       rs764889640       rs765112719       rs765309903       rs765347613       rs765379741       rs765791616       rs765843111       rs765853355       rs766156589       rs766210137       rs766664191       rs766712826       rs767756835       rs767893594       rs768590506       rs768742283       rs768797433       rs769302428       rs769446565       rs769498413       rs769731799       rs770166674       rs770213156       rs770314351       rs770408469       rs770959511       rs771116268       rs771127764       rs771296596       rs771306479       rs771454684       rs771508097       rs771712876       rs772023073       rs772073923       rs772166760       rs772219732       rs772666108       rs773027823       rs773233767       rs773750705       rs773803332       rs774130437       rs774457997       rs774565824       rs774923708       rs775226267       rs775605678       rs775707450       rs775888442       rs776094552       rs776147592       rs776158661       rs776270063       rs776467336       rs776927297       rs776981099       rs777171760       rs777221019       rs777246915       rs777752936       rs778175820       rs778668399       rs778915852       rs779236254       rs779704587       rs780164959       rs780557148       rs780667208       rs780775278       rs780797103       rs780903026       rs781146958       rs781232825       rs781491637      

基因表达

基因表达

HLA-DQA2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CACCAATGAGGTTCCTGAG
58
TCCACAAGACAGATGAGGG
59
CACCAATGAGGTTCCTGAG
58
CACAAGACAGATGAGGGTG
58
AAGACATTGTGGCTGACCA
60
ATTCATGGGTGTACTGGCC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

HLA-DQA2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

HLA-DQA2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0006955
A0A140TA34(UniProtKB)
IEA
GO:0019882
A0A140TA34(UniProtKB)
IEA
GO:0042613
A0A140TA34(UniProtKB)
IEA
GO:0000139
P01906(UniProtKB)
TAS
GO:0000139
P01906(UniProtKB)
TAS
GO:0005765
P01906(UniProtKB)
TAS
GO:0005765
P01906(UniProtKB)
TAS
GO:0005765
P01906(UniProtKB)
TAS
GO:0005765
P01906(UniProtKB)
TAS
GO:0005765
P01906(UniProtKB)
TAS
GO:0005765
P01906(UniProtKB)
TAS
GO:0005765
P01906(UniProtKB)
TAS
GO:0005765
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005886
P01906(UniProtKB)
TAS
GO:0005887
P01906(UniProtKB)
NAS
GO:0006955
P01906(UniProtKB)
NAS
GO:0010008
P01906(UniProtKB)
IEA
GO:0012507
P01906(UniProtKB)
TAS
GO:0012507
P01906(UniProtKB)
TAS
GO:0019886
P01906(UniProtKB)
TAS
GO:0030658
P01906(UniProtKB)
TAS
GO:0030658
P01906(UniProtKB)
TAS
GO:0030666
P01906(UniProtKB)
TAS
GO:0030666
P01906(UniProtKB)
TAS
GO:0030669
P01906(UniProtKB)
TAS
GO:0030669
P01906(UniProtKB)
TAS
GO:0031295
P01906(UniProtKB)
TAS
GO:0032395
P01906(UniProtKB)
NAS
GO:0032588
P01906(UniProtKB)
TAS
GO:0032588
P01906(UniProtKB)
TAS
GO:0032588
P01906(UniProtKB)
TAS
GO:0032588
P01906(UniProtKB)
TAS
GO:0032588
P01906(UniProtKB)
TAS
GO:0042613
P01906(UniProtKB)
IEA
GO:0050852
P01906(UniProtKB)
TAS
GO:0060333
P01906(UniProtKB)
TAS
GO:0071556
P01906(UniProtKB)
TAS
GO:0071556
P01906(UniProtKB)
TAS
GO:0071556
P01906(UniProtKB)
TAS
GO:0071556
P01906(UniProtKB)
TAS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控HLA-DQA2基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Rheumatoid Arthritis 0.123452799 6 8 BeFree_CTD_human_GAD
Hepatitis B, Chronic 0.120542884 3 1 BeFree_GWASCAT
Diabetes Mellitus, Insulin-Dependent 0.018653544 61 2 BeFree_GAD
Celiac Disease 0.006786047 25 0 BeFree
Lupus Erythematosus, Systemic 0.003995683 7 3 BeFree_GAD
Graves Disease 0.003528744 13 0 BeFree
Asthma 0.003181358 4 0 BeFree_GAD
Narcolepsy 0.002909916 3 0 BeFree_GAD
Spontaneous abortion 0.002367032 1 0 GAD
Idiopathic Membranous Glomerulonephritis 0.002171535 8 2 BeFree
Juvenile dermatomyositis 0.001900093 7 0 BeFree
Diabetes Mellitus 0.001628651 6 2 BeFree
Dermatomyositis, Childhood Type 0.001628651 6 0 BeFree
Diabetes 0.001357209 5 2 BeFree
Autoimmune Diseases 0.001085767 4 0 BeFree
Multiple Sclerosis 0.001085767 4 0 BeFree
Psoriasis 0.001085767 4 2 BeFree
Cardiomyopathy, Familial Idiopathic 0.001085767 4 0 BeFree
Malignant neoplasm of breast 0.000814326 3 0 BeFree
Duodenal Ulcer 0.000814326 3 0 BeFree
Membranous glomerulonephritis 0.000814326 3 0 BeFree
Malignant neoplasm of stomach 0.000814326 3 0 BeFree
Myasthenia Gravis 0.000814326 3 0 BeFree
Myositis 0.000814326 3 0 BeFree
Vitiligo 0.000814326 3 0 BeFree
Gastric Adenocarcinoma 0.000814326 3 0 BeFree
Breast Carcinoma 0.000814326 3 0 BeFree
Stomach Carcinoma 0.000814326 3 0 BeFree
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) 0.000814326 3 0 BeFree
Disorder of eye 0.000542884 2 0 BeFree
Hepatitis B 0.000542884 2 0 BeFree
Keloid 0.000542884 2 0 BeFree
Liver Cirrhosis 0.000542884 2 2 BeFree
Mitral Valve Stenosis 0.000542884 2 0 BeFree
Systemic Scleroderma 0.000542884 2 0 BeFree
Aortic Aneurysm, Abdominal 0.000542884 2 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.000542884 2 0 BeFree
Hepatitis C, Chronic 0.000542884 2 0 BeFree
Helicobacter pylori infection 0.000542884 2 0 BeFree
Chronic iridocyclitis 0.000542884 2 0 BeFree
Juvenile rheumatoid arthritis 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Arthritis 0.000271442 1 0 BeFree
Malignant tumor of cervix 0.000271442 1 3 BeFree
Cystic Fibrosis 0.000271442 1 0 BeFree
Dermatitis Herpetiformis 0.000271442 1 0 BeFree
Scleroderma 0.000271442 1 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Esophageal Achalasia 0.000271442 1 0 BeFree
Fatigue 0.000271442 1 0 BeFree
Gastritis, Atrophic 0.000271442 1 0 BeFree
Irritable Bowel Syndrome 0.000271442 1 0 BeFree
Leishmaniasis, Visceral 0.000271442 1 0 BeFree
Leprosy 0.000271442 1 2 BeFree
Liver diseases 0.000271442 1 0 BeFree
Lymphoma 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Pancreatitis 0.000271442 1 0 BeFree
Rheumatic Fever 0.000271442 1 0 BeFree
Rosacea 0.000271442 1 0 BeFree
Ankylosing spondylitis 0.000271442 1 0 BeFree
Takayasu Arteritis 0.000271442 1 0 BeFree
Thymoma 0.000271442 1 0 BeFree
Squamous cell carcinoma of lung 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Pauciarticular juvenile rheumatoid arthritis 0.000271442 1 0 BeFree
Autoimmune thyroid disease 0.000271442 1 0 BeFree
Congenital diaphragmatic hernia 0.000271442 1 0 BeFree
Hereditary pancreatitis 0.000271442 1 0 BeFree
Rheumatic mitral stenosis 0.000271442 1 0 BeFree
Squamous cell carcinoma of esophagus 0.000271442 1 0 BeFree
Cervix carcinoma 0.000271442 1 3 BeFree
Common acute lymphoblastic leukemia 0.000271442 1 0 BeFree
Steroid-sensitive nephrotic syndrome 0.000271442 1 0 BeFree
Seropositive rheumatoid arthritis 0.000271442 1 0 BeFree
Neonatal Systemic lupus erythematosus 0.000271442 1 0 BeFree
Myasthenia Gravis, Ocular 0.000271442 1 0 BeFree
Idiopathic Inflammatory Myopathies 0.000271442 1 0 BeFree
Gluten sensitivity 0.000271442 1 0 BeFree
Cervical Dystonia 0.000271442 1 0 BeFree
Diffuse Scleroderma 0.000271442 1 0 BeFree
Localized vitiligo 0.000271442 1 0 BeFree
Generalized vitiligo 0.000271442 1 0 BeFree

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