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Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
[中文简述(自动翻译):]  
CHIT1基因(以及对应的蛋白质)的细胞分布位置:
CHIT1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Gaucher Disease | 0.125991584 | 4 | 0 | BeFree_CTD_human_LHGDN |
CHITOTRIOSIDASE DEFICIENCY | 0.12 | 0 | 2 | CLINVAR |
Leukemia, Myelocytic, Acute | 0.005634266 | 2 | 0 | BeFree_GAD_LHGDN |
Sarcoidosis | 0.0054487 | 2 | 0 | LHGDN |
Tuberculosis | 0.005091382 | 1 | 0 | GAD_LHGDN |
Asthma | 0.004267125 | 7 | 0 | BeFree_GAD |
Malaria | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Atherosclerosis | 0.00272435 | 1 | 0 | LHGDN |
beta Thalassemia | 0.00272435 | 1 | 0 | LHGDN |
Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Globoid cell leukodystrophy | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Niemann-Pick Disease, Type B | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
Juvenile arthritis | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Hypertensive disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Gram-Negative Bacterial Infections | 0.002638474 | 2 | 0 | BeFree_GAD |
Sepsis | 0.002638474 | 1 | 0 | BeFree_GAD |
Coronary Artery Disease | 0.002638474 | 1 | 0 | BeFree_GAD |
Bacterial Infections | 0.002367032 | 1 | 0 | GAD |
Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Gram-Positive Bacterial Infections | 0.002367032 | 1 | 0 | GAD |
Mycoses | 0.000814326 | 3 | 0 | BeFree |
Filariasis | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Exanthema | 0.000271442 | 1 | 0 | BeFree |
Hookworm Infections | 0.000271442 | 1 | 0 | BeFree |
Lung Diseases, Fungal | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
Osteoarthritis of hip | 0.000271442 | 1 | 0 | BeFree |
Parasitic Diseases | 0.000271442 | 1 | 0 | BeFree |
Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Childhood asthma | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Severe chronic obstructive pulmonary disease | 0.000271442 | 1 | 0 | BeFree |
Spots on skin | 0.000271442 | 1 | 0 | BeFree |
Monocytoid B-cell lymphoma | 0.000271442 | 1 | 0 | BeFree |
Degenerative disorder | 0.000271442 | 1 | 0 | BeFree |
Inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
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