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The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一个锌指转录因子,并包含一个N-末端POZ域。该蛋白质作为转录的序列特异性阻抑,并且已显示调节的启动依赖的IL-4的B细胞应答的转录。该蛋白可与各种转录辅阻遏物是功能含POZ蛋白的相互作用。该基因被发现要经常易位和弥漫性大细胞淋巴瘤(DLCL)超突变,并可能参与DLCL的发病机制。已发现该基因编码不同的蛋白质亚型选择性剪接转录变异体。 [由RefSeq的,2008年9月提供]
BCL6基因(以及对应的蛋白质)的细胞分布位置:
BCL6基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Lymphoma, Follicular | 0.15999522 | 72 | 0 | BeFree_GAD_LHGDN_ORPHANET |
Lymphoma, Non-Hodgkin | 0.135154595 | 21 | 0 | BeFree_CTD_human_GAD_LHGDN |
T-Cell Lymphoma | 0.120814326 | 4 | 0 | BeFree_CTD_human |
Mediastinal (Thymic) Large B-Cell Lymphoma | 0.120271442 | 1 | 0 | BeFree_ORPHANET |
B-Cell Lymphomas | 0.08261122 | 140 | 0 | BeFree_GAD_LHGDN |
Lymphoma | 0.065073612 | 146 | 0 | BeFree_GAD_LHGDN |
Diffuse Large B-Cell Lymphoma | 0.033311405 | 115 | 1 | BeFree_GAD |
Leukemogenesis | 0.012214884 | 45 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.010606096 | 19 | 0 | BeFree_LHGDN |
Chronic Lymphocytic Leukemia | 0.005624334 | 12 | 0 | BeFree_GAD |
Myeloid Leukemia, Chronic | 0.005005506 | 3 | 0 | BeFree_GAD |
HIV Infections | 0.004267125 | 8 | 0 | BeFree_GAD |
Hodgkin Disease | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Burkitt Lymphoma | 0.003528744 | 13 | 0 | BeFree |
Malignant neoplasm of breast | 0.003257302 | 12 | 0 | BeFree |
Carcinogenesis | 0.003257302 | 12 | 0 | BeFree |
Breast Carcinoma | 0.003257302 | 12 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Immunoproliferative Small Intestinal Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Lymphoma, AIDS-Related | 0.002909916 | 3 | 0 | BeFree_GAD |
Ataxia | 0.00272435 | 1 | 0 | LHGDN |
Metaplasia | 0.00272435 | 1 | 0 | LHGDN |
Otitis Media with Effusion | 0.00272435 | 1 | 0 | LHGDN |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Waldenstrom Macroglobulinemia | 0.002367032 | 1 | 0 | GAD |
Pathologic Neovascularization | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Central Nervous System Neoplasms | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of lung | 0.002367032 | 1 | 0 | GAD |
Atopy | 0.002367032 | 1 | 0 | GAD |
Congenital chromosomal disease | 0.002171535 | 8 | 0 | BeFree |
leukemia | 0.002171535 | 8 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.002171535 | 8 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.001900093 | 7 | 0 | BeFree |
Gastric lymphoma | 0.001900093 | 7 | 0 | BeFree |
Lymphoproliferative Disorders | 0.001357209 | 5 | 0 | BeFree |
Multiple Myeloma | 0.001357209 | 5 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.001357209 | 5 | 0 | BeFree |
Primary central nervous system lymphoma | 0.001357209 | 5 | 0 | BeFree |
Marginal Zone B-Cell Lymphoma | 0.001357209 | 5 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001357209 | 5 | 0 | BeFree |
Acute lymphocytic leukemia | 0.001085767 | 4 | 0 | BeFree |
Trisomy | 0.001085767 | 4 | 0 | BeFree |
Acquired Immunodeficiency Syndrome | 0.000814326 | 3 | 0 | BeFree |
Common Variable Immunodeficiency | 0.000814326 | 3 | 0 | BeFree |
Reticulosarcoma | 0.000814326 | 3 | 0 | BeFree |
Peripheral T-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Aggressive Non-Hodgkin Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Leukemia, B-Cell | 0.000814326 | 3 | 0 | BeFree |
Angioimmunoblastic Lymphadenopathy | 0.000542884 | 2 | 0 | BeFree |
Lymphoid leukemia | 0.000542884 | 2 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Small Noncleaved-Cell | 0.000542884 | 2 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
High grade B-cell lymphoma | 0.000542884 | 2 | 0 | BeFree |
Hepatitis C, Chronic | 0.000542884 | 2 | 0 | BeFree |
Monocytoid B-cell lymphoma | 0.000542884 | 2 | 0 | BeFree |
Primary Effusion Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000542884 | 2 | 0 | BeFree |
Mature B-Cell Non-Hodgkin Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Gastric Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Diffuse | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Developmental Disabilities | 0.000271442 | 1 | 0 | BeFree |
Chordoma | 0.000271442 | 1 | 0 | BeFree |
Congenital ocular coloboma (disorder) | 0.000271442 | 1 | 0 | BeFree |
Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
Exanthema | 0.000271442 | 1 | 0 | BeFree |
Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
Fetal Alcohol Syndrome | 0.000271442 | 1 | 0 | BeFree |
pathologic fistula | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
Infectious Mononucleosis | 0.000271442 | 1 | 0 | BeFree |
Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Meningioma | 0.000271442 | 1 | 0 | BeFree |
Monosomy | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Superinfection | 0.000271442 | 1 | 0 | BeFree |
synovial sarcoma | 0.000271442 | 1 | 0 | BeFree |
Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
Fibromatosis, Aggressive | 0.000271442 | 1 | 0 | BeFree |
Immunoblastic Large-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Precursor cell lymphoblastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Complete trisomy 18 syndrome | 0.000271442 | 1 | 0 | BeFree |
T-Lymphocytopenia, Idiopathic CD4-Positive | 0.000271442 | 1 | 0 | BeFree |
Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
HTLV Infections | 0.000271442 | 1 | 0 | BeFree |
Lymphoid interstitial pneumonia | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Gallbladder adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Acute Undifferentiated Leukemia | 0.000271442 | 1 | 0 | BeFree |
stage, chronic lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Diffuse Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Intraocular Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Post-transplant lymphoproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
Composite Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
early pregnancy | 0.000271442 | 1 | 0 | BeFree |
Malignant Peripheral Nerve Sheath Tumor | 0.000271442 | 1 | 0 | BeFree |
Perineurioma | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Solitary fibrous tumor | 0.000271442 | 1 | 0 | BeFree |
Primary cutaneous B-cell lymphoma | 0.000271442 | 1 | 0 | BeFree |
Cutaneous lymphoma | 0.000271442 | 1 | 0 | BeFree |
AIDS-Related Non-Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Classical Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Primary Cutaneous Follicle Center Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Grade 3b Follicular Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Nodular Lymphocyte Predominant Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Undifferentiated leukemia | 0.000271442 | 1 | 0 | BeFree |
Astler-Coller B1 Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Primary cutaneous large B-cell lymphoma of the leg | 0.000271442 | 1 | 0 | BeFree |
Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type | 0.000271442 | 1 | 0 | BeFree |
Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
LATERAL MENINGOCELE SYNDROME | 0.000271442 | 1 | 0 | BeFree |
Philadelphia chromosome-positive acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Low grade glioma | 0.000271442 | 1 | 0 | BeFree |
Hodgkin lymphoma, nodular lymphocyte predominance | 0.000271442 | 1 | 0 | BeFree |
Pediatric Follicular Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
Plasmablastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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