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题目:: Linkage analysis of 26 Canadian breast and breast-ovarian cancer families.
作者:: Tonin(P),Moslehi(R),Green(R),Rosen(B),Cole(D),Boyd(N),Cutler(C),Margolese(R),Carter(R),McGillivray(B)
状态:: 发布时间1995-06-27 , 更新时间 2015-11-19
期刊:: Hum Genet
摘要:: We have examined 26 Canadian families with hereditary breast or ovarian cancer for linkage to markers flanking the BRCA1 gene on chromosome 17q12-q21. Of the 15 families that contain cases of ovarian cancer, 94% were estimated to be linked to BRCA1. In contrast, there was no overall evidence of linkage in the group of 10 families with breast cancer without ovarian cancer. A genetic recombinant in a breast-ovarian cancer family indicates a placement of BRCA1 telomeric to D17S776, and helps to define the region of assignment of the cancer susceptibility gene. Other cancers of interest that appeared in the BRCA1-linked families included primary peritoneal cancer, cancer of the fallopian tube, and malignant melanoma.
语言:: eng
DOI:

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