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题目:: K-ras gene mutations in early colorectal cancer ... flat elevated vs polyp-forming cancer....
作者:: Hasegawa(H),Ueda(M),Watanabe(M),Teramoto(T),Mukai(M),Kitajima(M)
状态:: 发布时间1995-05-30 , 更新时间 2004-11-17
期刊:: Oncogene
摘要:: K-ras gene mutations in early colorectal cancer were detected by two-step sensitive polymerase chain reaction (PCR) and enzyme digestion method. Early colorectal cancer was classified into flat elevated cancer or polyp-forming cancer according to morphology and presence of adenomatous components. A total of 60 paraffin-embedded tissue specimens from patients with early colorectal cancer were analysed. K-ras codon 12 mutations were detected in 23.3% (7/30) of flat elevated cancer and 63.3% (19/30) of polyp-forming cancer. The incidence of K-ras codon 12 mutations in flat elevated cancer was significantly lower than in polyp-forming cancer (P < 0.01). These data suggested that K-ras gene mutations may be correlated with morphology or clinical features in flat elevated cancer, and that flat elevated cancer may originate from a pathway different from adenoma-carcinoma sequence.
语言:: eng
DOI:

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