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题目:: Small bowel adenocarcinoma and associated malignancies.
作者:: Ahmed(S),Shahid(R K),Sami(A),Ahmad(I),Yadav(S),Mirchandani(D),Popkin(D),Haider(K)
状态:: 发布时间2016-12-12 , 更新时间 2016-12-12
期刊:: J Clin Oncol
摘要:: 4088 Background: Small bowel (SB) tumors are uncommon and comprise only 1-5% of gastrointestinal cancers. In the Western countries, adenocarcinoma is the most common SB tumor and represents about 28-47% of all malignant SB tumors. Limited data is available about second malignancies in SB adenocarcinoma. Our experience of second malignancies in patients with SB adenocarcinoma in a Canadian province is presented here.,Patients with SB adenocarcinoma and a second malignancy diagnosed since 1958 were identified by using Saskatchewan Cancer Registry. Patients with colo-rectal cancer with extension to the SB or with metastatic adenocarcinoma to SB were excluded.,Twenty-two patients with SB cancer and a second cancer were identified. The median age was 73 yrs (17-81) and M: F was 1:1. 7/17 (41%) patients had smoking history and 11/14 (79%) patients had history of alcohol intake. Family history was available in 16 patients and 8/16 (50%) patients had at least 1 (1-3) first degree relative with cancer. Seventy-seven percent patients had localized disease at the time of diagnosis. Sites of involvement were as follows: Duodenum 36%, Ileum 36%, and Jejunum 27%. All except 1 patient underwent curative or palliative resection of the tumor. None had received adjuvant therapy. The median time from the diagnosis of SB adenocarcinoma to a second malignancy was 8. 5 years (0-30). Six patients had ≥1 second cancer. In 32% patients, SB adenocarcinoma was the first cancer diagnosed. Median number of second cancers was 1 (1-4) and a total of 31 second cancers were diagnosed. The frequency of second cancers were as follows: Colon cancer 45%, breast cancer 23%, prostate cancer 13%, lung cancer 6%, rectal cancer 3%, thyroid cancer 3%, cervical cancer 3%, and ovarian cancer 3%. Median follow up period was 12.5 yrs (1-36). 24% with localized SB cancer had recurrence of the disease after curative resection. Median survival from the time of diagnosis of SB adneocarcinoma was 4 yrs (0.1-29).15 patients died during follow up period. 60% patients died of small bowel cancer and 27% died of second cancer.,An association was noted between SB adenocarcinoma and colo-rectal cancer. Moreover, a long latency period was found between SB adenocarcinoma and a second cancer. No significant financial relationships to disclose.
语言:: eng
DOI:

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