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题目:: The metabolic fate of acetate in cancer.
作者:: Schug(Zachary T),Vande Voorde(Johan),Gottlieb(Eyal)
状态:: 发布时间2016-09-30 , 更新时间 2016-10-25
期刊:: Nat Rev Cancer
摘要:: Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.
语言:: eng
DOI:: 10.1038/nrc.2016.87

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