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题目:: Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer.
作者:: Pawelek(John M)
状态:: 发布时间2014-03-04 , 更新时间 2015-05-15
期刊:: Chin J Cancer
摘要:: This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.
语言:: eng
DOI:

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