| GeneLibs

题目:: Estrogen signaling in lung cancer: an opportunity for novel therapy.
作者:: Baik(Christina S),Eaton(Keith D)
状态:: 发布时间2013-11-11 , 更新时间 2016-12-06
期刊:: Cancers (Basel)
摘要:: Lung cancer is the leading cause of cancer death in U.S. and represents a major public health burden. Epidemiologic data have suggested that lung cancer in women may possess different biological characteristics compared to men, as evidenced by a higher proportion of never-smokers among women with lung cancer. Emerging data indicate that female hormones such as estrogen and progesterone play a significant role in lung carcinogenesis. It has been reported that estrogen and progesterone receptors are expressed in lung cancer cell lines as well as in patient-derived tumors. Hormone related risk factors such as hormone replacement therapy have been implicated in lung carcinogenesis and several preclinical studies show activity of anti-estrogen therapy in lung cancer. In this review, we summarize the emerging evidence for the role of reproductive hormones in lung cancer and implications for lung cancer therapy.
语言:: eng
DOI:

文献库文献相关信息