| GeneLibs

题目:: A novel model of dormancy for bone metastatic breast cancer cells.
作者:: Marlow(Rebecca),Honeth(Gabriella),Lombardi(Sara),Cariati(Massimiliano),Hessey(Sonya),Pipili(Aikaterini),Mariotti(Veronica),Buchupalli(Bharath),Foster(Katie),Bonnet(Dominique),Grigoriadis(Agamemnon),Rameshwar(Pranela),Purushotham(Anand),Tutt(Andrew),Dontu(Gabriela)
状态:: 发布时间2013-12-03 , 更新时间 2015-07-08
期刊:: Cancer Res
摘要:: Mortality of patients with breast cancer is due overwhelmingly to metastatic spread of the disease. Although dissemination is an early event in breast cancer, extended periods of cancer cell dormancy can result in long latency of metastasis development. Deciphering the mechanisms underlying cancer cell dormancy and subsequent growth at the metastatic site would facilitate development of strategies to interfere with these processes. A challenge in this undertaking has been the lack of models for cancer cell dormancy. We have established novel experimental systems that model the bone microenvironment of the breast cancer metastatic niche. These systems are based on 3D cocultures of breast cancer cells with cell types predominant in bone marrow. We identified conditions in which cancer cells are dormant and conditions in which they proliferate. Dormant cancer cells were able to proliferate upon transfer into supportive microenvironment or upon manipulation of signaling pathways that control dormancy. These experimental systems will be instrumental for metastasis studies, particularly the study of cellular dormancy.
语言:: eng
DOI:: 10.1158/0008-5472.CAN-13-0991

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息