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题目:: Deja Vu: EGF receptors drive resistance to BRAF inhibitors.
作者:: Girotti(Maria Romina),Marais(Richard)
状态:: 发布时间2013-05-09 , 更新时间 2016-11-22
期刊:: Cancer Discov
摘要:: The promise of personalized medicine is upon us, and in some cancers, targeted therapies are rapidly becoming the mainstay of treatment for selected patients based on their molecular profile. The protein kinase BRAF is a driver oncogene in both thyroid cancer and melanoma, but while drugs that target BRAF and its downstream signaling pathway are effective in melanoma, they are ineffective in thyroid cancer. In this issue of Cancer Discovery, Montero-Conde and colleagues investigate why thyroid cancer is resistant to BRAF inhibitors despite the presence of BRAF mutation.
语言:: eng
DOI:

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