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题目:: Tumor-derived tenascin-C promotes the epithelial-mesenchymal transition in colorectal cancer cells.
作者:: Takahashi(Yusuke),Sawada(Genta),Kurashige(Junji),Matsumura(Tae),Uchi(Ryutaro),Ueo(Hiroki),Ishibashi(Masahisa),Takano(Yuki),Akiyoshi(Sayuri),Iwaya(Takeshi),Eguchi(Hidetoshi),Sudo(Tomoya),Sugimachi(Keishi),Yamamoto(Hirofumi),Doki(Yuichiro),Mori(Masaki),Mimori(Koshi)
状态:: 发布时间2013-05-06 , 更新时间 2015-11-19
期刊:: Anticancer Res
摘要:: Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed. We investigated the clinical significance of cancer-derived TNC in colorectal cancer (CRC) cases.,TNC expression in 170 cases of CRC was analyzed by quantitative real-time polymerase chain reaction (PCR). In addition, gene expression arrays using purely-separated cancer tissues of another 86 cases was performed and the functional implications of cancer-specific TNC were investigated.,The expression of TNC mRNA was significantly higher in CRC tissues than in the corresponding normal tissues. Cancer cell-specific TNC expression was a significant prognostic factor in CRC cases. Moreover, cancer cell-derived TNC was associated with the epithelial-mesenchymal transition (EMT) signature.,Cancer cell-derived TNC promotes cancer invasiveness via EMT regulation, and not cancer tissue TNC but cancer cell-specific TNC is a novel indicator of poor prognosis.
语言:: eng
DOI:

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