Molecular archeology: unearthing androgen-induced structural rearrangements in prostate cancer genomes.
作者:
Demichelis(Francesca),Garraway(Levi A),Rubin(Mark A)
状态:
发布时间2013-02-15
, 更新时间 2016-10-19
期刊:
Cancer Cell
摘要:
In this issue of Cancer Cell, Weischenfeldt and colleagues report on the whole genome sequencing of 11 early-onset prostate cancers. Compared to elderly onset prostate cancer, these tumors demonstrate enrichment for androgen-driven structural rearrangements involving ETS family genes. This study confirms observations that prostate cancer manifests discrete genomic subclasses.