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题目:: Increasing potential of HER3 signaling in colon cancer progression and therapy.
作者:: Gespach(Christian)
状态:: 发布时间2012-02-16 , 更新时间 2014-11-20
期刊:: Clin Cancer Res
摘要:: HER3 protein levels at the cancer cell plasma membrane are directly correlated with reduced survival in patients with colorectal cancer. In colorectal cancer cells, HER3 blockade restricted cellular growth (G(2)-M arrest), survival, migration, and invasion, and potentiated the chemotherapeutic effect of 5-FU, supporting strategies that target HER3 in subsets of patients with colorectal cancer.
语言:: eng
DOI:: 10.1158/1078-0432.CCR-11-3143

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