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题目:: Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
作者:: Molokwu(Chidi N),Adeniji(Olajumoke O),Chandrasekharan(Shankar),Hamdy(Freddie C),Buttle(David J)
状态:: 发布时间2010-07-19 , 更新时间 2016-11-25
期刊:: Cancer Invest
摘要:: Prostate cancer is a major cause of mortality, largely as a consequence of metastases and transformation to androgen-independent growth. Metalloproteinases are implicated in cancer progression. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are expressed in prostate cancer cells, with ADAMTS-1 and ADAMTS-15 being the most abundant. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene. ADAMTS-15 expression is predictive for survival in breast cancer, and the situation may be similar in prostate cancer, as androgen independence is usually due to aberrant signaling through its receptor.
语言:: eng
DOI:: 10.3109/07357907.2010.489538

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