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题目:: Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report.
作者:: Brassesco(M S),Valera(E T),Castro-Gamero(A M),Moreno(D A),Silveira(T P),Mori(B M),Engel(E E),Scrideli(C A),Tone(L G)
状态:: 发布时间2009-10-29 , 更新时间 2009-10-29
期刊:: Genet Mol Res
摘要:: Epithelioid sarcoma is a rare, aggressive soft tissue tumor of unknown histogenesis showing predominantly epithelioid cytomorphology. We conducted a conventional and molecular cytogenetic study of a 27-year-old male with epithelioid sarcoma with angiomatoid features. Cytogenetic analysis of epithelioid sarcoma metaphase spreads by GTG-banding revealed a diploid chromosome complement with structural and numerical aberrations. Comparative genomic hybridization analysis demonstrated the amplification of 3p24-pter, 4p15.2-p16 and 18q23, while chromosome losses involved 3p13-p14, 3q24-q26.1, 9q21, and 11q21. Fluorescence in situ hybridization assessment showed normal hybridization patterns for the C-MYC and CCND1 loci; CCND1 RNA overexpression was detected by real-time polymerase chain reaction analysis. Genetic evaluation of this rare condition may be useful in determining if epithelioid sarcoma is associated with a distinct genetic background.
语言:: eng
DOI:: 10.4238/vol8-4gmr656

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