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题目:: Rapid progression of prostate cancer in men with a BRCA2 mutation.
作者:: Narod(S A),Neuhausen(S),Vichodez(G),Armel(S),Lynch(H T),Ghadirian(P),Cummings(S),Olopade(O),Stoppa-Lyonnet(D),Couch(F),Wagner(T),Warner(E),Foulkes(W D),Saal(H),Weitzel(J),Tulman(A),Poll(A),Nam(R),Sun(P),,Danquah(Jessica),Domchek(Susan),Tung(Nadine),Ainsworth(Peter),Horsman(Douglas),Kim-Sing(Charmaine),Maugard(Christine),Eisen(Andrea),Daly(Mary),McKinnon(Wendy),Wood(Marie),Isaacs(Claudine),Gilchrist(Dawna),Karlan(Beth),Nedelcu(Raluca),Meschino(Wendy),Garber(Judy),Pasini(Barbara),Manoukian(Siranoush),Bellati(Christina)
状态:: 发布时间2008-07-16 , 更新时间 2016-11-22
期刊:: Br J Cancer
摘要:: Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.
语言:: eng
DOI:

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