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题目:: Changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer.
作者:: Wang(Lin-Bo),Jiang(Zhi-Nong),Fan(Miao-Ying),Xu(Chao-Yang),Chen(Wen-Jun),Shen(Jian-Guo)
状态:: 发布时间2008-03-11 , 更新时间 2015-11-19
期刊:: World J Gastroenterol
摘要:: To investigate the changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer.,One hundred and seventy-seven gastric cancer patients with lymph node and/or distal metastasis between 1997 and 2001 were reviewed. Differences in histology of the primary and metastatic gastric cancer were assessed. MMP-2 and nm23-H1 immunoreactivity was compared in 44 patients with tumor infiltration to the serosa layer.,Poorly and moderately differentiated metastatic gastric cancer was found in 88.7% (157/177) and primary gastric cancer in 75.7% (134/177) of the patients. The histological type of metastatic gastric cancer that was not completely in accordance with the preponderant histology of primary gastric cancer was observed in 25 patients (14.1%). MMP-2 immunoreactivity in metastatic gastric cancer was significantly stronger than that in primary gastric cancer, while nm23-H1 immunoreactivity showed no difference in primary and metastatic gastric cancer.,Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer. This heterogeneity may elicit a possible mechanism of gastric cancer metastasis.
语言:: eng
DOI:

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