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题目:: Expression profile of class I histone deacetylases in human cancer tissues.
作者:: Nakagawa(Masamune),Oda(Yoshinao),Eguchi(Takashi),Aishima(Shin-Ichi),Yao(Takashi),Hosoi(Fumihito),Basaki(Yuji),Ono(Mayumi),Kuwano(Michihiko),Tanaka(Masao),Tsuneyoshi(Masazumi)
状态:: 发布时间2007-09-05 , 更新时间 2009-11-19
期刊:: Oncol Rep
摘要:: Histone deacetylase (HDAC) activity is one of the widely used and well-established mechanisms for regulation of various genes in cancer. To identify which subtype of class I HDACs are overexpressed in cancers, we analyzed the expression of class I HDAC isotypes composed of HDAC1, 2, 3 and 8 in several cell lines and human cancer tissues, including cancer of the stomach, esophagus, colon, prostate, breast, ovary, lung, pancreas and thyroid. The results showed that >75% of human cancer tissues and their corresponding non-cancerous epithelium showed high expression of these class I HDACs. However, the immunoreactivity of HDAC8 in both prostatic cancer tissue and non-cancerous prostate glands was lower than that in other cancer tissues. Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers.
语言:: eng
DOI:

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