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题目:: Analysis of differences in clinicopathological features between prostate cancers located in the transition and peripheral zones.
作者:: Sakai(Iori),Harada(Ken-ichi),Kurahashi(Toshifumi),Yamanaka(Kazuki),Hara(Isao),Miyake(Hideaki)
状态:: 发布时间2006-05-31 , 更新时间 2006-11-15
期刊:: Int J Urol
摘要:: The objective of this study was to retrospectively characterize differences in the clinicopathological features of prostate cancer according to the zonal origin.,Among 185 consecutive patients who underwent radical prostatectomy without any neoadjuvant hormonal therapies, this study included 134 patients who were diagnosed as having either transition zone (TZ) or peripheral zone (PZ) cancer according to the following criteria: TZ or PZ cancers were considered when more than 70% of the cancer area was located in the TZ or PZ, respectively. The various clinicopathological features were then compared according to this classification.,In this series, 27 patients were diagnosed as having TZ cancer, while the remaining 107 were diagnosed as having PZ cancer. The percent of positive biopsy cores in TZ cancers was significantly lower than that in PZ cancers; however, there were no significant differences in the anatomical location of positive cores between these two groups except for the middle of prostate where TZ cancer showed a significantly lower rate of positive biopsies than PZ cancer. The preoperative serum prostate-specific antigen (PSA) value in patients with TZ cancer was significantly higher than that in those with PZ cancer. Furthermore, tumor volume in TZ cancers was significantly greater than that in PZ cancers. However, there was no significant difference in biochemical recurrence-free survival between patients with TZ and PZ cancers.,Despite the significantly high PSA value as well as great tumor volume compared with those of PZ cancers, TZ cancers had similar biochemical cure rates following radical prostatectomy, suggesting a less aggressive phenotype of TZ cancers than that of PZ cancers.
语言:: eng
DOI:: 10.1111/j.1442-2042.2006.01307.x

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