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题目:: A candidate gene approach to searching for low-penetrance breast and prostate cancer genes.
作者:: Hunter(D J),Riboli(E),Haiman(C A),Albanes(D),Altshuler(D),Chanock(S J),Haynes(R B),Henderson(B E),Kaaks(R),Stram(D O),Thomas(G),Thun(M J),Blanché(H),Buring(J E),Burtt(N P),Calle(E E),Cann(H),Canzian(F),Chen(Y C),Colditz(G A),Cox(D G),Dunning(A M),Feigelson(H S),Freedman(M L),Gaziano(J M),Giovannucci(E),Hankinson(S E),Hirschhorn(J N),Hoover(R N),Key(T),Kolonel(L N),Kraft(P),Le Marchand(L),Liu(S),Ma(J),Melnick(S),Pharaoh(P),Pike(M C),Rodriguez(C),Setiawan(V W),Stampfer(M J),Trapido(E),Travis(R),Virtamo(J),Wacholder(S),Willett(W C),
状态:: 发布时间2005-12-12 , 更新时间 2016-10-25
期刊:: Nat Rev Cancer
摘要:: Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium--a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer--was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers--the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway--and to associate these variations with cancer risk.
语言:: eng
DOI:: 10.1038/nrc1754

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