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题目:: Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse.
作者:: Tervonen(Topi),Akerman(Karl),Oostra(Ben A),Castrén(Maija)
状态:: 发布时间2005-01-21 , 更新时间 2006-11-15
期刊:: Brain Res Mol Brain Res
摘要:: In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65% from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling.
语言:: eng
DOI:: 10.1016/j.molbrainres.2004.09.023

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