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题目:: Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers.
作者:: Pan(Qiangrong),Fang(Yongming),Xu(Yang),Zhang(Kun),Hu(Xun)
状态:: 发布时间2004-12-24 , 更新时间 2006-11-15
期刊:: Cancer Lett
摘要:: Human DNA polymerases kappa, eta, iota, and zeta are responsible for the translesion DNA synthesis. Numerous in vitro studies indicated that these enzymes may contribute to DNA lesion-triggered and spontaneous mutation. We measured the transcripts of these 4 enzymes in 131 self-paired cancerous and non-tumor samples, including 23 lung cancers, 49 stomach cancers, and 59 colorectal cancers. Our results indicated that, except pol eta in colorectal cancers, these enzymes are all significantly down-regulated in human lung, stomach, and colorectal cancers, suggesting that these enzymes are probably not closely associated with the elevated mutations in human cancer.
语言:: eng
DOI:: 10.1016/j.canlet.2004.07.021

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