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题目:: Hereditary diffuse gastric cancer.
作者:: Dunbier(A),Guilford(P)
状态:: 发布时间2001-10-22 , 更新时间 2006-11-15
期刊:: Adv Cancer Res
摘要:: Hereditary diffuse gastric cancer (HDGC) is a cancer predisposition syndrome caused by germline mutation of the gene for the cell-to-cell adhesion protein E-cadherin. The syndrome is dominated by predisposition to the histologically diffuse, poorly differentiated form of gastric cancer. It is not associated with intestinal-type gastric cancer, but families may have an elevated risk of lobular breast cancer. Here, we review the identified families, mutations, and proposed mechanisms by which E-cadherin loss promotes tumorigenesis.
语言:: eng
DOI:

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