SRC (SRC proto-oncogene, non-receptor tyrosine kinase)
- symbol:
- SRC
- locus group:
- protein-coding gene
- location:
- 20q11.23
- gene_family:
- SH2 domain containing
- alias symbol:
- ASV|c-src
- alias name:
- None
- entrez id:
- 6714
- ensembl gene id:
- ENSG00000197122
- ucsc gene id:
- uc002xgy.5
- refseq accession:
- NM_005417
- hgnc_id:
- HGNC:11283
- approved reserved:
- 2001-06-22
SRC基因是一种原癌基因（proto-oncogene），属于SRC家族酪氨酸激酶基因家族（SRC family kinases，SFKs），该家族成员（如LYN、FYN等）均编码非受体型酪氨酸激酶（non-receptor tyrosine kinases），通过磷酸化靶蛋白调控细胞信号传导。SRC基因编码的SRC蛋白在细胞增殖、分化、黏附、迁移等过程中起核心作用，其活性受C端酪氨酸残基（Tyr530）磷酸化的负调控，当该位点去磷酸化时，SRC激酶被激活。SRC突变（如Tyr530突变或激酶结构域突变）会导致组成性激活（持续活化），促进肿瘤发生，与结肠癌、乳腺癌等多种癌症相关。SRC过表达会增强下游信号通路（如MAPK、PI3K/AKT），导致细胞异常增殖和转移；而敲低SRC表达会抑制肿瘤生长，但可能影响正常组织的伤口愈合和骨代谢（因SRC参与破骨细胞活化）。SRC家族基因的共性是含有SH3、SH2结构域（介导蛋白相互作用）和激酶结构域（催化磷酸化），并通过调控细胞骨架重组和整合素信号影响肿瘤侵袭性。目前针对SRC的靶向药物（如达沙替尼）用于治疗白血病，但需注意其可能引起的心脏毒性等副作用。
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
该基因是高度相似劳斯肉瘤病毒的v型的src基因。这个原癌基因可能在胚胎发育和细胞生长的调节作用。由该基因编码的蛋白质是一个酪氨酸 - 蛋白激酶，其活性可以通过磷酸化的c-Src激酶被抑制。在这个基因的突变可能是参与结肠癌的恶性进展。已发现了该基因编码的蛋白质相同的两个转录变异体。 [由RefSeq的，2008年7月提供]
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TTTGCTGGACTTTCTCAAGG
58
TGTAAGCAGACCTGAGCAG
59
GAAACCAGATGAGGACGCT
59
GGGTCTCGAAATAGAGGCC
59
GTCCTTCAAGAAAGGCGAG
58
AAATACCACTCCTCAGCCTG
59
CTTTCCTCCCTCCTTCTGTC
59
AAATACCACTCCTCAGCCTG
59
TATGACTATGAGTCTAGGACGGA
59
TCTCCCTCTGTGTTGTTGAC
59
TATGCTGTGGTTTCAGAGG
57
GAAAGTCCAGCAAACTCCC
58
TGAAGACAATGAGTACACGG
57
TTGTGGTGAGCTCAGTCAG
59
TGCTGGACTTTCTCAAGGG
59
CTGTAAGCAGACCTGAGCA
59
GAAGACAATGAGTACACGGC
59
TTGTGGTGAGCTCAGTCAG
59
GTCCTTCAAGAAAGGCGAG
58
AAATACCACTCCTCAGCCT
58
基因本体信息
SRC基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
SRC基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0002223
P12931 (UniProtKB)
TAS
GO:0004672
P12931 (UniProtKB)
IDA
GO:0004672
P12931 (UniProtKB)
TAS
GO:0004672
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
IDA
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
IDA
GO:0004713
P12931 (UniProtKB)
EXP
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004713
P12931 (UniProtKB)
TAS
GO:0004715
P12931 (UniProtKB)
TAS
GO:0005070
P12931 (UniProtKB)
TAS
GO:0005080
P12931 (UniProtKB)
IEA
GO:0005102
P12931 (UniProtKB)
IPI
GO:0005158
P12931 (UniProtKB)
IEA
GO:0005178
P12931 (UniProtKB)
TAS
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005515
P12931 (UniProtKB)
IPI
GO:0005524
P12931 (UniProtKB)
IEA
GO:0005634
P12931 (UniProtKB)
IEA
GO:0005737
P12931 (UniProtKB)
IDA
GO:0005737
P12931 (UniProtKB)
IDA
GO:0005739
P12931 (UniProtKB)
IDA
GO:0005743
P12931 (UniProtKB)
IDA
GO:0005764
P12931 (UniProtKB)
IDA
GO:0005770
P12931 (UniProtKB)
IDA
GO:0005829
P12931 (UniProtKB)
IDA
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005829
P12931 (UniProtKB)
TAS
GO:0005884
P12931 (UniProtKB)
IEA
GO:0005886
P12931 (UniProtKB)
IDA
GO:0005886
P12931 (UniProtKB)
IDA
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005886
P12931 (UniProtKB)
TAS
GO:0005901
P12931 (UniProtKB)
IDA
GO:0007049
P12931 (UniProtKB)
IEA
GO:0007165
P12931 (UniProtKB)
TAS
GO:0007165
P12931 (UniProtKB)
TAS
GO:0007172
P12931 (UniProtKB)
TAS
GO:0007173
P12931 (UniProtKB)
IBA
GO:0007173
P12931 (UniProtKB)
TAS
GO:0007179
P12931 (UniProtKB)
IMP
GO:0007229
P12931 (UniProtKB)
IMP
GO:0007417
P12931 (UniProtKB)
IBA
GO:0008022
P12931 (UniProtKB)
IEA
GO:0008283
P12931 (UniProtKB)
IEA
GO:0009612
P12931 (UniProtKB)
IEA
GO:0009615
P12931 (UniProtKB)
IEA
GO:0010447
P12931 (UniProtKB)
IEA
GO:0010632
P12931 (UniProtKB)
IMP
GO:0010634
P12931 (UniProtKB)
IMP
GO:0010641
P12931 (UniProtKB)
IEA
GO:0010907
P12931 (UniProtKB)
IEA
GO:0014069
P12931 (UniProtKB)
IEA
GO:0014911
P12931 (UniProtKB)
IEA
GO:0016032
P12931 (UniProtKB)
IEA
GO:0016301
P12931 (UniProtKB)
TAS
GO:0016337
P12931 (UniProtKB)
IEA
GO:0018105
P12931 (UniProtKB)
IEA
GO:0018108
P12931 (UniProtKB)
IDA
GO:0019899
P12931 (UniProtKB)
IPI
GO:0019900
P12931 (UniProtKB)
IPI
GO:0020037
P12931 (UniProtKB)
IDA
GO:0022407
P12931 (UniProtKB)
IMP
GO:0030168
P12931 (UniProtKB)
TAS
GO:0030331
P12931 (UniProtKB)
IEA
GO:0030520
P12931 (UniProtKB)
IBA
GO:0030900
P12931 (UniProtKB)
IEA
GO:0031234
P12931 (UniProtKB)
IBA
GO:0031295
P12931 (UniProtKB)
TAS
GO:0031295
P12931 (UniProtKB)
TAS
GO:0031648
P12931 (UniProtKB)
IEA
GO:0031667
P12931 (UniProtKB)
IEA
GO:0031954
P12931 (UniProtKB)
IEA
GO:0032148
P12931 (UniProtKB)
IEA
GO:0032211
P12931 (UniProtKB)
IMP
GO:0032463
P12931 (UniProtKB)
IMP
GO:0032587
P12931 (UniProtKB)
IEA
GO:0032869
P12931 (UniProtKB)
IEA
GO:0033146
P12931 (UniProtKB)
IEA
GO:0033625
P12931 (UniProtKB)
TAS
GO:0034332
P12931 (UniProtKB)
IEA
GO:0034446
P12931 (UniProtKB)
IEA
GO:0034614
P12931 (UniProtKB)
IEA
GO:0035556
P12931 (UniProtKB)
IDA
GO:0036035
P12931 (UniProtKB)
IBA
GO:0036120
P12931 (UniProtKB)
IEA
GO:0038083
P12931 (UniProtKB)
IBA
GO:0038096
P12931 (UniProtKB)
TAS
GO:0038128
P12931 (UniProtKB)
TAS
GO:0042127
P12931 (UniProtKB)
IBA
GO:0042169
P12931 (UniProtKB)
IPI
GO:0042493
P12931 (UniProtKB)
IEA
GO:0042542
P12931 (UniProtKB)
IEA
GO:0043005
P12931 (UniProtKB)
IEA
GO:0043065
P12931 (UniProtKB)
IEA
GO:0043066
P12931 (UniProtKB)
IMP
GO:0043114
P12931 (UniProtKB)
TAS
GO:0043149
P12931 (UniProtKB)
IMP
GO:0043154
P12931 (UniProtKB)
IMP
GO:0043393
P12931 (UniProtKB)
IEA
GO:0043406
P12931 (UniProtKB)
IEA
GO:0043552
P12931 (UniProtKB)
IEA
GO:0044325
P12931 (UniProtKB)
IPI
GO:0044325
P12931 (UniProtKB)
IPI
GO:0045056
P12931 (UniProtKB)
IEA
GO:0045087
P12931 (UniProtKB)
IBA
GO:0045124
P12931 (UniProtKB)
TAS
GO:0045453
P12931 (UniProtKB)
ISS
GO:0045737
P12931 (UniProtKB)
IEA
GO:0045892
P12931 (UniProtKB)
IEA
GO:0045893
P12931 (UniProtKB)
IEA
GO:0046628
P12931 (UniProtKB)
IEA
GO:0046777
P12931 (UniProtKB)
IDA
GO:0046875
P12931 (UniProtKB)
IPI
GO:0048008
P12931 (UniProtKB)
IBA
GO:0048010
P12931 (UniProtKB)
TAS
GO:0048011
P12931 (UniProtKB)
IEA
GO:0048013
P12931 (UniProtKB)
TAS
GO:0048471
P12931 (UniProtKB)
IEA
GO:0048477
P12931 (UniProtKB)
IEA
GO:0050715
P12931 (UniProtKB)
IEA
GO:0050731
P12931 (UniProtKB)
IC
GO:0050847
P12931 (UniProtKB)
ISS
GO:0050847
P12931 (UniProtKB)
IBA
GO:0050900
P12931 (UniProtKB)
TAS
GO:0051219
P12931 (UniProtKB)
IPI
GO:0051385
P12931 (UniProtKB)
IEA
GO:0051427
P12931 (UniProtKB)
IBA
GO:0051602
P12931 (UniProtKB)
IEA
GO:0051726
P12931 (UniProtKB)
IBA
GO:0051895
P12931 (UniProtKB)
ISS
GO:0051897
P12931 (UniProtKB)
IMP
GO:0051902
P12931 (UniProtKB)
IMP
GO:0051974
P12931 (UniProtKB)
IMP
GO:0060065
P12931 (UniProtKB)
IEA
GO:0060444
P12931 (UniProtKB)
IEA
GO:0060491
P12931 (UniProtKB)
IEA
GO:0070062
P12931 (UniProtKB)
IDA
GO:0070062
P12931 (UniProtKB)
IDA
GO:0070062
P12931 (UniProtKB)
IDA
GO:0070374
P12931 (UniProtKB)
IEA
GO:0070374
P12931 (UniProtKB)
IEA
GO:0070555
P12931 (UniProtKB)
IMP
GO:0070851
P12931 (UniProtKB)
IPI
GO:0071222
P12931 (UniProtKB)
IEA
GO:0071375
P12931 (UniProtKB)
ISS
GO:0071393
P12931 (UniProtKB)
ISS
GO:0071398
P12931 (UniProtKB)
IEA
GO:0071456
P12931 (UniProtKB)
IEA
GO:0071498
P12931 (UniProtKB)
IEA
GO:0071801
P12931 (UniProtKB)
IBA
GO:0071803
P12931 (UniProtKB)
IEA
GO:0071902
P12931 (UniProtKB)
IDA
GO:0086098
P12931 (UniProtKB)
ISS
GO:0090263
P12931 (UniProtKB)
IEA
GO:0097110
P12931 (UniProtKB)
IPI
GO:2000394
P12931 (UniProtKB)
IMP
GO:2000573
P12931 (UniProtKB)
IEA
GO:2000641
P12931 (UniProtKB)
IMP
GO:2000811
P12931 (UniProtKB)
IMP
GO:2001237
P12931 (UniProtKB)
IMP
GO:2001243
P12931 (UniProtKB)
IMP
GO:2001286
P12931 (UniProtKB)
IMP
| 名称 |
|---|
| 4015 Rap1 signaling pathway [PATH:hsa04015] |
| 4012 ErbB signaling pathway [PATH:hsa04012] |
| 4370 VEGF signaling pathway [PATH:hsa04370] |
| 4144 Endocytosis [PATH:hsa04144] |
| 4810 Regulation of actin cytoskeleton [PATH:hsa04810] |
| 4510 Focal adhesion [PATH:hsa04510] |
| 4520 Adherens junction [PATH:hsa04520] |
| 4530 Tight junction [PATH:hsa04530] |
| 4540 Gap junction [PATH:hsa04540] |
| 4611 Platelet activation [PATH:hsa04611] |
| 4062 Chemokine signaling pathway [PATH:hsa04062] |
| 4912 GnRH signaling pathway [PATH:hsa04912] |
| 4915 Estrogen signaling pathway [PATH:hsa04915] |
| 4917 Prolactin signaling pathway [PATH:hsa04917] |
| 4921 Oxytocin signaling pathway [PATH:hsa04921] |
| 4919 Thyroid hormone signaling pathway [PATH:hsa04919] |
| 4727 GABAergic synapse [PATH:hsa04727] |
| 4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750] |
| 5205 Proteoglycans in cancer [PATH:hsa05205] |
| 5203 Viral carcinogenesis [PATH:hsa05203] |
| 5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120] |
| 5131 Shigellosis [PATH:hsa05131] |
| 5152 Tuberculosis [PATH:hsa05152] |
| 5100 Bacterial invasion of epithelial cells [PATH:hsa05100] |
| 5161 Hepatitis B [PATH:hsa05161] |
| 名称 |
|---|
| Adaptive Immune System |
| ADP signalling through P2Y purinoceptor 1 |
| Axon guidance |
| c-src mediated regulation of Cx43 function and closure of gap junctions |
| C-type lectin receptors (CLRs) |
| CD28 co-stimulation |
| Cell surface interactions at the vascular wall |
| Cell-Cell communication |
| CLEC7A (Dectin-1) signaling |
| Costimulation by the CD28 family |
| CTLA4 inhibitory signaling |
| DCC mediated attractive signaling |
| Developmental Biology |
| Downstream signal transduction |
| EPH-ephrin mediated repulsion of cells |
| EPH-Ephrin signaling |
| EPHA-mediated growth cone collapse |
| EPHB-mediated forward signaling |
| Ephrin signaling |
| Fcgamma receptor (FCGR) dependent phagocytosis |
| FCGR activation |
| GAB1 signalosome |
| Gap junction trafficking and regulation |
| GP1b-IX-V activation signalling |
| GRB2:SOS provides linkage to MAPK signaling for Integrins |
| Hemostasis |
| Innate Immune System |
| Integrin alphaIIb beta3 signaling |
| L1CAM interactions |
| Membrane Trafficking |
| NCAM signaling for neurite out-growth |
| Negative regulation of FGFR1 signaling |
| Negative regulation of FGFR2 signaling |
| Negative regulation of FGFR3 signaling |
| Negative regulation of FGFR4 signaling |
| Netrin mediated repulsion signals |
| Netrin-1 signaling |
| NGF signalling via TRKA from the plasma membrane |
| p130Cas linkage to MAPK signaling for integrins |
| p38MAPK events |
| PECAM1 interactions |
| Platelet activation, signaling and aggregation |
| Platelet Aggregation (Plug Formation) |
| Recycling pathway of L1 |
| Regulation of gap junction activity |
| Regulation of KIT signaling |
| RHO GTPase Effectors |
| RHO GTPases Activate Formins |
| Signal amplification |
| Signal regulatory protein (SIRP) family interactions |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by PDGF |
| Signaling by Rho GTPases |
| Signaling by SCF-KIT |
| Signaling by VEGF |
| Signalling by NGF |
| Signalling to ERKs |
| Signalling to RAS |
| Spry regulation of FGF signaling |
| Thrombin signalling through proteinase activated receptors (PARs) |
| VEGFA-VEGFR2 Pathway |
| VEGFR2 mediated cell proliferation |
| Vesicle-mediated transport |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Status Epilepticus | 0.2 | 1 | 0 | CTD_human_RGD |
| Mammary Neoplasms | 0.143152011 | 14 | 0 | BeFree_CTD_human_LHGDN |
| Colonic Neoplasms | 0.131440285 | 7 | 0 | BeFree_CTD_human_LHGDN |
| Bladder Neoplasm | 0.12 | 2 | 0 | CTD_human |
| Neoplasm Invasiveness | 0.12 | 2 | 0 | CTD_human |
| Colitis | 0.12 | 1 | 0 | CTD_human |
| Cardiomegaly | 0.12 | 1 | 0 | CTD_human |
| Autosomal Recessive Polycystic Kidney Disease | 0.12 | 1 | 0 | CTD_human |
| Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Cerebrovascular accident | 0.08 | 1 | 0 | RGD |
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