RPSA (ribosomal protein SA)
- symbol:
- RPSA
- locus group:
- protein-coding gene
- location:
- 3p22.1
- gene_family:
- alias symbol:
- LRP|37LRP|p40|SA
- alias name:
- None
- entrez id:
- 3921
- ensembl gene id:
- ENSG00000168028
- ucsc gene id:
- uc003cjp.4
- refseq accession:
- NM_002295
- hgnc_id:
- HGNC:6502
- approved reserved:
- 1992-06-03
RPSA（核糖体蛋白SA）是一种重要的核糖体蛋白，属于核糖体蛋白家族，该家族成员普遍参与核糖体的组装和蛋白质的翻译过程。RPSA基因编码的蛋白质是40S核糖体亚基的组成部分，在蛋白质合成中发挥关键作用。除了参与翻译，RPSA还作为层粘连蛋白受体（LAMR1）在细胞表面表达，参与细胞粘附、信号传导和病毒感染等过程。RPSA的突变可能导致核糖体功能异常，影响蛋白质合成效率，进而引发核糖体病（如Diamond-Blackfan贫血）或与癌症发展相关。研究表明，RPSA在某些肿瘤（如乳腺癌、肝癌）中过表达，可能通过促进细胞增殖、迁移和侵袭参与肿瘤进展。降低RPSA表达可能抑制肿瘤生长，但同时也可能影响正常细胞的蛋白质合成。RPSA还参与病毒感染过程，如登革热病毒和SARS-CoV-2利用其作为受体进入细胞。该基因属于核糖体蛋白基因家族，该家族成员通常高度保守，在物种间具有相似的结构和功能，主要参与维持核糖体稳定性和翻译调控。RPSA的多功能性使其成为研究癌症、病毒感染和核糖体相关疾病的重要靶点。
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
层粘连蛋白，一个家庭的细胞外基质糖蛋白，是基底膜的主要非胶原成分。他们已牵涉在多种生物学过程，包括细胞粘着，分化，迁移，信令，神经突向外生长和转移。许多的层粘连蛋白的作用是通过与细胞表面受体的相互作用介导的。这些受体包括整联蛋白家族的成员，以及非整层粘连蛋白结合蛋白。这个基因编码的高亲和力，非整联蛋白家族，层粘连蛋白受体1该受体被不同地称为67 kD的层粘连蛋白受体，37 kD的层粘连蛋白受体的前体（37LRP）和p40核糖体相关蛋白。层粘连蛋白受体1的氨基酸序列在进化过程中高度保守，提示键生物学功能。已经观察到层粘连蛋白受体转录物的水平是在结肠癌组织和肺癌细胞系比它们的正常对应更高。此外，还有在癌细胞这种多肽的上调和它们的侵袭和转移表型之间的相关性。该基因的多个副本存在，但是，他们大多是认为从retropositional事件出现假。已发现此基因的两个编码相同蛋白质可变剪接转录物变体。 [由RefSeq的，2008年7月提供]
基因本体信息
RPSA基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
RPSA基因的本体（GO）信息：
| 名称 |
|---|
| 3010 Ribosome [PATH:hsa03010] |
| 名称 |
|---|
| 3' -UTR-mediated translational regulation |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| Cap-dependent Translation Initiation |
| Disease |
| Eukaryotic Translation Elongation |
| Eukaryotic Translation Initiation |
| Eukaryotic Translation Termination |
| Formation of a pool of free 40S subunits |
| Formation of the ternary complex, and subsequently, the 43S complex |
| Gene Expression |
| GTP hydrolysis and joining of the 60S ribosomal subunit |
| Infectious disease |
| Influenza Infection |
| Influenza Life Cycle |
| Influenza Viral RNA Transcription and Replication |
| L13a-mediated translational silencing of Ceruloplasmin expression |
| Metabolism of proteins |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| Nonsense-Mediated Decay (NMD) |
| Peptide chain elongation |
| Ribosomal scanning and start codon recognition |
| SRP-dependent cotranslational protein targeting to membrane |
| Translation |
| Translation initiation complex formation |
| Viral mRNA Translation |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Splenic Hypoplasia | 0.120271442 | 1 | 0 | BeFree_ORPHANET |
| Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
| ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 5 (disorder) | 0.08 | 0 | 0 | MGD |
| Neoplasm Metastasis | 0.004885954 | 18 | 0 | BeFree |
| Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Leukemia, Myelocytic, Acute | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.002171535 | 8 | 0 | BeFree |
| Stomach Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Carcinoma of lung | 0.001628651 | 6 | 0 | BeFree |
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