RPS5 (ribosomal protein S5)
- symbol:
- RPS5
- locus group:
- protein-coding gene
- location:
- 19q13.43
- gene_family:
- S ribosomal proteins
- alias symbol:
- S5
- alias name:
- 40S ribosomal protein S5
- entrez id:
- 6193
- ensembl gene id:
- ENSG00000083845
- ucsc gene id:
- uc002qsn.4
- refseq accession:
- NM_001009
- hgnc_id:
- HGNC:10426
- approved reserved:
- 1997-07-07
RPS5（核糖体蛋白S5）是核糖体小亚基的组成蛋白之一，属于核糖体蛋白（Ribosomal Proteins, RPs）基因家族。该家族编码的蛋白质共同参与核糖体的组装和蛋白质翻译过程，维持细胞基础功能。RPS5在核糖体40S亚基中发挥结构支撑作用，并参与mRNA解码和翻译起始调控。其表达产物具有高度保守性，在真核生物中广泛存在。突变可能影响核糖体功能，导致翻译错误或效率下降，引发核糖体病（Ribosomopathies），如戴蒙德-布莱克范贫血（Diamond-Blackfan anemia, DBA），表现为红细胞生成障碍。该基因与肿瘤关系密切，某些癌症中可见RPS5拷贝数增加，其过表达可能通过异常激活核糖体生物合成途径促进癌细胞增殖；而表达降低则可能导致p53依赖的细胞周期阻滞。RPS5还参与DNA损伤响应，其缺失会触发核糖体应激反应。核糖体蛋白家族的共性在于：均由高度保守的多基因编码，部分成员具有核糖体组装外的额外功能（如调控凋亡或细胞周期），且常作为“核糖体监视系统”的传感器协调细胞应激反应。专业术语解释：核糖体（蛋白质合成工厂）、mRNA（携带遗传信息的模板）、p53（抑癌蛋白）。英文注释：核糖体（ribosome）、核糖体病（ribosomopathy）。
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
核糖体，催化蛋白质合成的细胞器，由一个小40S亚基和60S大亚基。一起这些亚基组成的4 RNA种类和大约80结构不同的蛋白质。该基因编码一种核糖体蛋白，它是40S亚基的一个组成部分。该蛋白属于S7P家族核糖体的蛋白质。它位于细胞质中。该基因在相比邻近正常组织的结肠直肠癌的可变表达已经观察到，虽然表达水平与疾病的严重程度之间没有相关性已被发现。作为典型编码核糖体蛋白的基因，有该基因通过基因组分散的多个经处理的假基因。 [由RefSeq的，2008年7月提供]
基因本体信息
RPS5基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
RPS5基因的本体（GO）信息：
| 名称 |
|---|
| 3010 Ribosome [PATH:hsa03010] |
| 名称 |
|---|
| 3' -UTR-mediated translational regulation |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| Cap-dependent Translation Initiation |
| Disease |
| Eukaryotic Translation Elongation |
| Eukaryotic Translation Initiation |
| Eukaryotic Translation Termination |
| Formation of a pool of free 40S subunits |
| Formation of the ternary complex, and subsequently, the 43S complex |
| Gene Expression |
| GTP hydrolysis and joining of the 60S ribosomal subunit |
| Infectious disease |
| Influenza Infection |
| Influenza Life Cycle |
| Influenza Viral RNA Transcription and Replication |
| L13a-mediated translational silencing of Ceruloplasmin expression |
| Metabolism of proteins |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| Nonsense-Mediated Decay (NMD) |
| Peptide chain elongation |
| Ribosomal scanning and start codon recognition |
| SRP-dependent cotranslational protein targeting to membrane |
| Translation |
| Translation initiation complex formation |
| Viral mRNA Translation |
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