PRMT1 (protein arginine methyltransferase 1)

symbol:
PRMT1
locus group:
protein-coding gene
location:
19q13.33
gene_family:
Protein arginine methyltransferases
alias symbol:
HCP1|ANM1
alias name:
highly conserved protein 1
entrez id:
3276
ensembl gene id:
ENSG00000126457
ucsc gene id:
uc002ppe.4
refseq accession:
NM_001536
hgnc_id:
HGNC:5187
approved reserved:
1996-10-02
19q13.33
基因染色体位置图

PRMT1(蛋白质精氨酸甲基转移酶1)属于PRMT基因家族,该家族共有9个成员(PRMT1-9),主要功能是通过催化精氨酸残基的甲基化修饰调控蛋白质功能,参与基因表达调控、信号转导和RNA加工等过程。PRMT1是I型PRMT,催化生成不对称二甲基精氨酸(ADMA),在组蛋白和非组蛋白甲基化中发挥核心作用。PRMT1的生物学功能广泛,包括调控转录激活(如甲基化组蛋白H4R3促进染色质开放)、DNA损伤修复(通过甲基化53BP1等修复蛋白)、细胞增殖与分化(影响p53、NF-κB等信号通路)以及mRNA剪接(甲基化剪接因子如SMN)。其作用位点集中在细胞核和细胞质,与多种蛋白质相互作用。PRMT1突变或表达异常会导致严重疾病,如突变可能引起神经发育障碍或癌症(如白血病、乳腺癌中常见过表达),其异常甲基化活性还与心血管疾病和神经退行性疾病相关。过表达PRMT1会促进肿瘤生长、转移和化疗耐药(如通过甲基化EGFR增强其活性),同时抑制抑癌基因功能;而敲低PRMT1会导致细胞周期阻滞、凋亡增加(如p53通路激活)和DNA修复缺陷。PRMT1与家族其他成员共享催化结构域,但底物特异性不同,例如PRMT5生成对称二甲基精氨酸(SDMA)。PRMT家族共性包括依赖S-腺苷甲硫氨酸(SAM)作为甲基供体、参与表观遗传调控和细胞应激响应。PRMT1是当前癌症治疗的靶点,小分子抑制剂(如MS023)正在临床试验中研究。

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

这个基因编码精氨酸N-甲基转移酶(PRMT)家族蛋白质的成员。通过PRMTs靶蛋白的翻译后修饰起着许多生物过程,由此PRMTs由甲基基团从S-腺苷-L-甲硫氨酸转移至终端胍氮原子甲基化的精氨酸残基的重要的调节作用。所编码的蛋白质是I型PRMT并负责大多数蜂窝精氨酸甲基活性。该基因的表达增加可以许多类型的癌症中发挥作用。另外剪接转录变体编码多种亚型已经观察到这种基因,而这种基因的假基因位于[由RefSeq的,2011年12月提供的]的5号染色体长臂

PRMT1基因的碱基序列:[NCBI]
Loading Gene Browser...
PRMT1基因的碱基突变:           仅显示部分snp
rs35270176       rs62128125       rs71353323       rs73588418       rs74633762       rs76245510       rs79865986       rs113178727       rs114684010       rs117772384       rs140347063       rs141919954       rs143560194       rs147134564       rs148400131       rs148513044       rs149743671      

PRMT1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGTGGTGACCATCATCAAGG
59
ATGTCCACCTTCTCCACTG
59
TTCAACATCGAGTTCACACG
58
TAGAACACCGTCTGCTTCC
59
CTACTTTGACTCCTACGCAC
58
TGGAGTTGCGGTAAGTGAG
59
TATTTGTTGAGCTGGGATGTG
58
ATAGATGTCCACCTCTCCTC
57
CACCTCTTCAAGGACAAGGT
59
AACACTCGATCCCGATGAC
59
CGCCTCTTGAAGAAGTAAATATCC
59
ATATTGATGTGGAGGTCAGGG
59
CTACAAGATCCACTGGTGGG
59
GTCCACGACATCCACTAGG
59
GATGGAGAAATCCAAGGGC
58
GATGGTGAAGTCCAGGTCC
59
CTTTGACTCCTACGCACAC
58
CATGGAGTTGCGGTAAGTG
58
CGCCTCTTGAAGAAGTAAATATCC
59
TATTGATGTGGAGGTCAGGG
58
转录因子
影响基因
影响类型
参考文献链接(PubMed)
PIAS1
PRMT1
Repression

PRMT1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

PRMT1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0006479
A0A087X1W2 (UniProtKB)
IEA
GO:0008168
A0A087X1W2 (UniProtKB)
IEA
GO:0006479
E9PIX6 (UniProtKB)
IEA
GO:0008168
E9PIX6 (UniProtKB)
IEA
GO:0006479
E9PKG1 (UniProtKB)
IEA
GO:0008168
E9PKG1 (UniProtKB)
IEA
GO:0006479
E9PMW9 (UniProtKB)
IEA
GO:0008168
E9PMW9 (UniProtKB)
IEA
GO:0006479
E9PMZ2 (UniProtKB)
IEA
GO:0008168
E9PMZ2 (UniProtKB)
IEA
GO:0006479
E9PNR9 (UniProtKB)
IEA
GO:0008168
E9PNR9 (UniProtKB)
IEA
GO:0006479
E9PQ98 (UniProtKB)
IEA
GO:0008168
E9PQ98 (UniProtKB)
IEA
GO:0006479
H0YDE4 (UniProtKB)
IEA
GO:0008168
H0YDE4 (UniProtKB)
IEA
GO:0001701
H7C2I1 (UniProtKB)
IEA
GO:0016571
H7C2I1 (UniProtKB)
IEA
GO:0019919
H7C2I1 (UniProtKB)
IEA
GO:0035242
H7C2I1 (UniProtKB)
IEA
GO:0042054
H7C2I1 (UniProtKB)
IEA
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005515
Q99873 (UniProtKB)
IPI
GO:0005634
Q99873 (UniProtKB)
IDA
GO:0005654
Q99873 (UniProtKB)
TAS
GO:0005654
Q99873 (UniProtKB)
TAS
GO:0005654
Q99873 (UniProtKB)
TAS
GO:0005654
Q99873 (UniProtKB)
TAS
GO:0005737
Q99873 (UniProtKB)
TAS
GO:0005829
Q99873 (UniProtKB)
IBA
GO:0006355
Q99873 (UniProtKB)
IBA
GO:0006479
Q99873 (UniProtKB)
TAS
GO:0006977
Q99873 (UniProtKB)
TAS
GO:0007166
Q99873 (UniProtKB)
TAS
GO:0008168
Q99873 (UniProtKB)
TAS
GO:0008170
Q99873 (UniProtKB)
IDA
GO:0008170
Q99873 (UniProtKB)
IMP
GO:0008276
Q99873 (UniProtKB)
IDA
GO:0008327
Q99873 (UniProtKB)
IDA
GO:0016274
Q99873 (UniProtKB)
IDA
GO:0016274
Q99873 (UniProtKB)
TAS
GO:0016274
Q99873 (UniProtKB)
TAS
GO:0016274
Q99873 (UniProtKB)
TAS
GO:0016571
Q99873 (UniProtKB)
IDA
GO:0018216
Q99873 (UniProtKB)
IDA
GO:0018216
Q99873 (UniProtKB)
IDA
GO:0019899
Q99873 (UniProtKB)
IPI
GO:0019919
Q99873 (UniProtKB)
IEA
GO:0031175
Q99873 (UniProtKB)
IMP
GO:0034709
Q99873 (UniProtKB)
IDA
GO:0035242
Q99873 (UniProtKB)
IMP
GO:0042054
Q99873 (UniProtKB)
IDA
GO:0042802
Q99873 (UniProtKB)
IPI
GO:0042802
Q99873 (UniProtKB)
IPI
GO:0042802
Q99873 (UniProtKB)
IPI
GO:0043985
Q99873 (UniProtKB)
IDA
GO:0044020
Q99873 (UniProtKB)
IDA
GO:0044020
Q99873 (UniProtKB)
IMP
GO:0044822
Q99873 (UniProtKB)
IDA
GO:0045648
Q99873 (UniProtKB)
IMP
GO:0045653
Q99873 (UniProtKB)
IDA
GO:0046985
Q99873 (UniProtKB)
ISS
GO:0048273
Q99873 (UniProtKB)
IPI
GO:1900745
Q99873 (UniProtKB)
ISS

可能调控 PRMT1基因的相关microRNA:     

MINT

BioGrid

IntAct

mentha

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diabetic Nephropathy 0.080271442 1 0 BeFree_RGD
Asthma 0.080271442 2 0 BeFree_RGD
Malignant neoplasm of breast 0.003452799 4 0 BeFree_GAD
Colonic Neoplasms 0.00272435 1 0 LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Spina Bifida 0.002367032 1 0 GAD
Breast Carcinoma 0.001085767 4 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Neoplasm Metastasis 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree

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