NRG1 (neuregulin 1)

基因基本信息

基因基本信息

symbol:
NRG1
locus group:
protein-coding gene
location:
8p12
gene_family:
I-set domain containing
alias symbol:
HRG|NDF|GGF
alias name:
None
entrez id:
3084
ensembl gene id:
ENSG00000157168
ucsc gene id:
uc064luk.1
refseq accession:
NM_001159995
hgnc_id:
HGNC:7997
approved reserved:
1999-03-19

基因染色体位置

基因染色体位置

8p12
基因染色体位置图

基因简述

基因简述

NRG1（神经调节蛋白1）是一种属于表皮生长因子（EGF）家族的重要基因，编码的蛋白质在神经系统、心脏和乳腺等组织的发育和功能中起关键作用。NRG1通过激活ErbB受体酪氨酸激酶（特别是ErbB3和ErbB4）来传递信号，参与细胞增殖、分化、迁移和存活等过程。在神经系统中，NRG1对突触形成、髓鞘化和神经元存活至关重要；在心脏中，它调控心肌细胞的发育和功能；在乳腺中则影响导管生长和泌乳功能。NRG1基因突变可能导致其功能异常，与多种疾病相关，例如精神分裂症、双相情感障碍和乳腺癌。某些突变会破坏NRG1与ErbB受体的结合能力，影响下游信号通路，导致神经发育异常或肿瘤发生。NRG1过表达可能促进肿瘤生长和转移，尤其在乳腺癌中，高水平的NRG1可通过持续激活ErbB受体驱动癌细胞增殖。相反，NRG1表达降低可能导致神经发育缺陷、心脏功能异常或髓鞘形成障碍，例如在周围神经病变中观察到NRG1信号减弱。NRG1属于神经调节蛋白家族（NRG家族），该家族成员均含有EGF样结构域，能够激活ErbB受体，并在组织发育和稳态维持中发挥类似作用。家族成员（如NRG2、NRG3和NRG4）在功能上有部分重叠，但表达模式和生物学效应存在差异。NRG1是该家族中研究最深入的成员，因其广泛的生理和病理作用而备受关注。

The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014]

由该基因编码的蛋白质是一种膜糖蛋白，其介导细胞 - 细胞信号传导和起着多器官系统的增长和发展的关键作用。非凡多种不同的亚型是由该基因通过替代启动子用法和拼接产生的。这些同种型在组织特异性方式表达，并在它们的结构显著不同，并且被分类为类型I，II，III，IV，V和VI。这个基因的失调已被链接到的疾病，如癌症，精神分裂症和双相性精神障碍（BPD）。 [由RefSeq的，2014年6月提供]

OMIM数据库中对NRG1基因的介绍     Wikipedia数据库中对NRG1基因的介绍

基因序列

基因序列

NRG1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

NRG1基因的碱基突变：           仅显示部分snp
rs6989384       rs7001942       rs7016691       rs10503915       rs11415830       rs11774782       rs12216733       rs12681063       rs16879366       rs28569837       rs59323200       rs71512624       rs74512606       rs76638848       rs111538452       rs114281781       rs115638675      

基因表达

基因表达

NRG1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CCCTCGAGATACTTGTGCA
59
CAAGATGCTTGTAGAAGCTGG
59
ACCTACACTCAATGGATGCA
59
AGAACACAGAGACTTGTTGTC
58
CTTCTACAAGGCGGAGGAG
60
TCATATTGTTTCGTTCAGACCG
59
GATACTTGTGCAAGTGCCA
59
CTCTTCTGGTACAGCTCCT
58
AGATACTTGTGCAAGTGCC
58
GGACGTACTGTAGAAGCTG
57
CCCTCGAGATACTTGTGCA
59
CAAGATGCTTGTAGAAGCTGG
59
AAATAAAGCCTTGCCTCCC
58
TTCAGAACTGGTTTCACACC
58
CTCCTCATAGTGAAAGACATAACC
59
GCTGATAGCTGGATCTGCA
60
CCTACCTGCTGCAAATTCAC
60
CTGTCTTTCACTTTACCCAGC
59
TATGTGCAAAGTGATCAGCA
58
TGTAGATGTAGCGTTTGATTCC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

NRG1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

NRG1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005102
A0A0D9SF85 (UniProtKB)
IEA
GO:0009790
A0A0D9SF85 (UniProtKB)
IEA
GO:0005102
E5RHP6 (UniProtKB)
IEA
GO:0009790
E5RHP6 (UniProtKB)
IEA
GO:0016021
E5RHP6 (UniProtKB)
IEA
GO:0005102
E5RHQ1 (UniProtKB)
IEA
GO:0009790
E5RHQ1 (UniProtKB)
IEA
GO:0005102
E5RIG8 (UniProtKB)
IEA
GO:0009790
E5RIG8 (UniProtKB)
IEA
GO:0016021
E5RIG8 (UniProtKB)
IEA
GO:0005102
E7EX30 (UniProtKB)
IEA
GO:0009790
E7EX30 (UniProtKB)
IEA
GO:0016021
E7EX30 (UniProtKB)
IEA
GO:0005102
F6RJN6 (UniProtKB)
IEA
GO:0009790
F6RJN6 (UniProtKB)
IEA
GO:0016021
F6RJN6 (UniProtKB)
IEA
GO:0005102
H0YBA3 (UniProtKB)
IEA
GO:0009790
H0YBA3 (UniProtKB)
IEA
GO:0016021
H0YBA3 (UniProtKB)
IEA
GO:0005102
H0YCP0 (UniProtKB)
IEA
GO:0009790
H0YCP0 (UniProtKB)
IEA
GO:0005102
H0YDC2 (UniProtKB)
IEA
GO:0009790
H0YDC2 (UniProtKB)
IEA
GO:0016021
H0YDC2 (UniProtKB)
IEA
GO:0000165
Q02297 (UniProtKB)
TAS
GO:0000187
Q02297 (UniProtKB)
IMP
GO:0000902
Q02297 (UniProtKB)
IEA
GO:0001964
Q02297 (UniProtKB)
IEA
GO:0003161
Q02297 (UniProtKB)
IEA
GO:0003222
Q02297 (UniProtKB)
IDA
GO:0003712
Q02297 (UniProtKB)
IDA
GO:0004713
Q02297 (UniProtKB)
TAS
GO:0004713
Q02297 (UniProtKB)
TAS
GO:0004713
Q02297 (UniProtKB)
TAS
GO:0005088
Q02297 (UniProtKB)
TAS
GO:0005102
Q02297 (UniProtKB)
IPI
GO:0005125
Q02297 (UniProtKB)
TAS
GO:0005176
Q02297 (UniProtKB)
IEA
GO:0005178
Q02297 (UniProtKB)
IDA
GO:0005515
Q02297 (UniProtKB)
IPI
GO:0005515
Q02297 (UniProtKB)
IPI
GO:0005576
Q02297 (UniProtKB)
NAS
GO:0005576
Q02297 (UniProtKB)
NAS
GO:0005576
Q02297 (UniProtKB)
NAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005576
Q02297 (UniProtKB)
TAS
GO:0005615
Q02297 (UniProtKB)
IDA
GO:0005615
Q02297 (UniProtKB)
IDA
GO:0005615
Q02297 (UniProtKB)
IDA
GO:0005634
Q02297 (UniProtKB)
IEA
GO:0005737
Q02297 (UniProtKB)
IEA
GO:0005887
Q02297 (UniProtKB)
IEA
GO:0007154
Q02297 (UniProtKB)
TAS
GO:0007169
Q02297 (UniProtKB)
IDA
GO:0007171
Q02297 (UniProtKB)
IEA
GO:0007171
Q02297 (UniProtKB)
IDA
GO:0007399
Q02297 (UniProtKB)
TAS
GO:0007416
Q02297 (UniProtKB)
IEA
GO:0007422
Q02297 (UniProtKB)
IEA
GO:0007626
Q02297 (UniProtKB)
IEA
GO:0008083
Q02297 (UniProtKB)
IDA
GO:0008083
Q02297 (UniProtKB)
NAS
GO:0008217
Q02297 (UniProtKB)
IEA
GO:0008283
Q02297 (UniProtKB)
IDA
GO:0008284
Q02297 (UniProtKB)
IMP
GO:0009790
Q02297 (UniProtKB)
IEA
GO:0009897
Q02297 (UniProtKB)
IEA
GO:0010667
Q02297 (UniProtKB)
IDA
GO:0014032
Q02297 (UniProtKB)
TAS
GO:0014066
Q02297 (UniProtKB)
TAS
GO:0014068
Q02297 (UniProtKB)
IEA
GO:0015758
Q02297 (UniProtKB)
IEA
GO:0016020
Q02297 (UniProtKB)
NAS
GO:0016324
Q02297 (UniProtKB)
IDA
GO:0018108
Q02297 (UniProtKB)
IEA
GO:0021781
Q02297 (UniProtKB)
IEA
GO:0021842
Q02297 (UniProtKB)
IEA
GO:0030296
Q02297 (UniProtKB)
IDA
GO:0030297
Q02297 (UniProtKB)
NAS
GO:0030297
Q02297 (UniProtKB)
NAS
GO:0030297
Q02297 (UniProtKB)
IC
GO:0030307
Q02297 (UniProtKB)
IDA
GO:0030425
Q02297 (UniProtKB)
IEA
GO:0030673
Q02297 (UniProtKB)
IEA
GO:0030879
Q02297 (UniProtKB)
TAS
GO:0030971
Q02297 (UniProtKB)
NAS
GO:0030971
Q02297 (UniProtKB)
NAS
GO:0031594
Q02297 (UniProtKB)
IEA
GO:0031643
Q02297 (UniProtKB)
IEA
GO:0032148
Q02297 (UniProtKB)
IMP
GO:0035556
Q02297 (UniProtKB)
IBA
GO:0038127
Q02297 (UniProtKB)
IDA
GO:0038127
Q02297 (UniProtKB)
IMP
GO:0038128
Q02297 (UniProtKB)
TAS
GO:0042060
Q02297 (UniProtKB)
IDA
GO:0042060
Q02297 (UniProtKB)
TAS
GO:0042177
Q02297 (UniProtKB)
IEA
GO:0042552
Q02297 (UniProtKB)
IEA
GO:0043125
Q02297 (UniProtKB)
IPI
GO:0043125
Q02297 (UniProtKB)
IDA
GO:0043125
Q02297 (UniProtKB)
IDA
GO:0043496
Q02297 (UniProtKB)
TAS
GO:0043497
Q02297 (UniProtKB)
IDA
GO:0043547
Q02297 (UniProtKB)
IEA
GO:0043624
Q02297 (UniProtKB)
IGI
GO:0044297
Q02297 (UniProtKB)
IEA
GO:0045213
Q02297 (UniProtKB)
IEA
GO:0045499
Q02297 (UniProtKB)
IEA
GO:0045773
Q02297 (UniProtKB)
IEA
GO:0045785
Q02297 (UniProtKB)
IDA
GO:0045892
Q02297 (UniProtKB)
IDA
GO:0045944
Q02297 (UniProtKB)
IEA
GO:0046579
Q02297 (UniProtKB)
IEA
GO:0046854
Q02297 (UniProtKB)
IEA
GO:0046934
Q02297 (UniProtKB)
TAS
GO:0048015
Q02297 (UniProtKB)
TAS
GO:0048663
Q02297 (UniProtKB)
IEA
GO:0048709
Q02297 (UniProtKB)
IEA
GO:0050731
Q02297 (UniProtKB)
IEA
GO:0051048
Q02297 (UniProtKB)
IDA
GO:0051155
Q02297 (UniProtKB)
ISS
GO:0051897
Q02297 (UniProtKB)
IEA
GO:0055007
Q02297 (UniProtKB)
ISS
GO:0055012
Q02297 (UniProtKB)
IDA
GO:0060045
Q02297 (UniProtKB)
IDA
GO:0060379
Q02297 (UniProtKB)
IDA
GO:0060956
Q02297 (UniProtKB)
IDA
GO:0060999
Q02297 (UniProtKB)
IEA
GO:0061098
Q02297 (UniProtKB)
IEA
GO:0070886
Q02297 (UniProtKB)
IEA
GO:1903955
Q02297 (UniProtKB)
IMP
GO:2000010
Q02297 (UniProtKB)
IEA
GO:2000145
Q02297 (UniProtKB)
TAS
GO:2000727
Q02297 (UniProtKB)
IEA
GO:2001223
Q02297 (UniProtKB)
IEA
GO:2001240
Q02297 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 NRG1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Schizophrenia 0.330216746 209 5 BeFree_CTD_human_GAD_LHGDN
Mammary Neoplasms 0.137703311 11 0 BeFree_CTD_human_LHGDN
Hirschsprung Disease 0.124538567 9 1 BeFree_CTD_human_GAD
Heart failure 0.121085767 4 0 BeFree_CTD_human
Thyroid carcinoma 0.120271442 2 2 BeFree_GWASCAT
Neoplasm Invasiveness 0.12 1 0 CTD_human
Gastric ulcer 0.12 1 0 CTD_human
Contact Dermatitis 0.12 1 0 CTD_human
Polycystic Ovary Syndrome 0.12 1 0 CTD_human
Amphetamine-Related Disorders 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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