MDM2基因详情-基因数据库-基因云馆

登录系统

MDM2 (MDM2 proto-oncogene)

symbol:: MDM2
locus group:: protein-coding gene
location:: 12q15
gene_family:: Zinc fingers, RAN binding-type
alias symbol:: HDM2|MGC5370
alias name:: None
entrez id:: 4193
ensembl gene id:: ENSG00000135679
ucsc gene id:: uc001sui.6
refseq accession:: NM_002392
hgnc_id:: HGNC:6973
approved reserved:: 1993-12-10

12q15

MDM2（Mouse Double Minute 2）是一个重要的癌基因，属于MDM基因家族，该家族还包括MDM4等成员，主要功能是调控细胞周期和凋亡。MDM2基因编码的蛋白质是一种E3泛素连接酶，其最著名的功能是通过与肿瘤抑制蛋白p53结合来负调控p53的稳定性与活性。MDM2通过泛素化标记p53，促使其被蛋白酶体降解，从而抑制p53介导的细胞周期阻滞、DNA修复或凋亡。这一机制在正常细胞中帮助维持p53的低水平，但在癌症中MDM2的过表达会导致p53功能丧失，促进肿瘤发展。MDM2的作用位点主要集中在细胞核内，通过与p53的N端结构域结合发挥作用。MDM2基因的突变或扩增常见于多种癌症（如肉瘤、乳腺癌和胶质瘤），导致其过表达并抑制p53的抑癌功能。相反，MDM2表达降低可能增强p53活性，但过度激活p53也可能引发细胞凋亡或衰老。此外，MDM2还通过非p53依赖途径影响其他蛋白（如RB和FOXO）的稳定性，参与细胞增殖和应激反应调控。MDM2基因家族成员的共性是含有保守的环指结构域（负责泛素连接酶活性）和p53结合域，共同参与细胞稳态的精细调控。在治疗上，靶向MDM2的小分子抑制剂（如Nutlin-3）被开发用于恢复p53功能，但其应用需考虑p53突变状态以避免副作用。

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

该基因编码一个核本地化的E3泛素连接酶。所编码的蛋白质可通过靶向肿瘤抑制蛋白，如p53，对蛋白酶体降解促进肿瘤的形成。该基因是由p53基因本身转录上调。过表达或该基因座的扩增在各种不同的癌症的检测。有这个基因在染色体2.选择性剪接的结果在转录变异体，其中有许多可能只在肿瘤细胞中表达的大量假基因。 [由RefSeq的，2013年6月提供]

OMIM数据库中对MDM2基因的介绍 Wikipedia数据库中对MDM2基因的介绍

MDM2基因的碱基序列：[NCBI]

Loading Gene Browser...

MDM2基因的碱基突变：仅显示部分snp

rs1144944 rs2904506 rs3730485 rs3730486 rs3930427 rs35894537 rs79405001 rs113620585 rs115399919 rs140330247 rs145672681 rs147565886 rs181550785 rs188797510 rs370065863 rs529384532 rs535723930

MDM2基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TGTCTGTACCTACTGATGGTG

TCACTTTCTTACTAACCAGGGTC

TACTGTGTATCAGGCAGGG

GTGCATTTCCAATAGTCAGC

TCCTCCAAGCATTATTTGGAG

TAATGCTTTGAGGACCTCCA

TCTGTACCTACTGATGGTGC

CAATGGCTTTGGTCTAACCAG

TTCGGAACAAGAGACCCTG

GCATTTCCAATAGTCCCTGC

GAGTGAGAACAGGTGTCAC

AAGCTCTTGTACAAGGTCCT

GATGAAGATGATGAGGACTATTGG

ACATCTGTTGCAATGTGATGG

ATGTCTGTACCTACTGATGGTG

GCATTTCCAATAGTCCAGGG

CATCTACATTGCTGTCCTCC

TAATGCTTCGAGGACCTCC

CTCCAAAGGGATTAGTAGTTTACC

GATTCTGCTTGGTTGTAGCT

转录因子

影响基因

影响类型

参考文献链接（PubMed）

BRCA1

MDM2

Activation

11256609

E2F1

MDM2

Repression

20837136

ELF4

MDM2

Unknown

23393136

ELL

MDM2

Repression

15851483

EP300

MDM2

Unknown

11591713

ESR1

MDM2

Unknown

12897156

ETS1

MDM2

Repression

11424091

ETS2

MDM2

Activation

12750288

FOSL2

MDM2

Activation

22493372

FUS

MDM2

Repression

17234782

MDM2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

MDM2基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000122

A0A0C4DFR5 (UniProtKB)

IEA

GO:0008270

A0A0C4DFR5 (UniProtKB)

IEA

GO:0016567

A0A0C4DFR5 (UniProtKB)

IEA

GO:0000122

A7UKX7 (UniProtKB)

IEA

GO:0016567

A7UKX7 (UniProtKB)

IEA

GO:0000122

A7UKX8 (UniProtKB)

IEA

GO:0005634

A7UKX8 (UniProtKB)

IEA

GO:0016567

A7UKX8 (UniProtKB)

IEA

GO:0043066

A7UKX8 (UniProtKB)

IEA

GO:0071157

A7UKX8 (UniProtKB)

IEA

GO:0000122

A7UKY0 (UniProtKB)

IEA

GO:0005515

A7UKY0 (UniProtKB)

IPI

GO:0005730

A7UKY0 (UniProtKB)

IDA

GO:0042787

A7UKY0 (UniProtKB)

IMP

GO:0043066

A7UKY0 (UniProtKB)

IEA

GO:0071157

A7UKY0 (UniProtKB)

IEA

GO:0000122

E7EMW5 (UniProtKB)

IEA

GO:0008270

E7EMW5 (UniProtKB)

IEA

GO:0016567

E7EMW5 (UniProtKB)

IEA

GO:0000122

E7EPE2 (UniProtKB)

IEA

GO:0016567

E7EPE2 (UniProtKB)

IEA

GO:0000122

F5GWH7 (UniProtKB)

IEA

GO:0016567

F5GWH7 (UniProtKB)

IEA

GO:0000122

F5GZC3 (UniProtKB)

IEA

GO:0016567

F5GZC3 (UniProtKB)

IEA

GO:0000122

F5H1M7 (UniProtKB)

IEA

GO:0016567

F5H1M7 (UniProtKB)

IEA

GO:0000122

F5H4Q8 (UniProtKB)

IEA

GO:0005634

F5H4Q8 (UniProtKB)

IEA

GO:0016567

F5H4Q8 (UniProtKB)

IEA

GO:0043066

F5H4Q8 (UniProtKB)

IEA

GO:0071157

F5H4Q8 (UniProtKB)

IEA

GO:0000122

G3XA89 (UniProtKB)

IEA

GO:0005634

G3XA89 (UniProtKB)

IEA

GO:0008270

G3XA89 (UniProtKB)

IEA

GO:0016567

G3XA89 (UniProtKB)

IEA

GO:0043066

G3XA89 (UniProtKB)

IEA

GO:0071157

G3XA89 (UniProtKB)

IEA

GO:0000122

J3KN53 (UniProtKB)

IEA

GO:0005634

J3KN53 (UniProtKB)

IEA

GO:0008270

J3KN53 (UniProtKB)

IEA

GO:0016567

J3KN53 (UniProtKB)

IEA

GO:0043066

J3KN53 (UniProtKB)

IEA

GO:0071157

J3KN53 (UniProtKB)

IEA

GO:0000122

J3QST1 (UniProtKB)

IEA

GO:0016567

J3QST1 (UniProtKB)

IEA

GO:0000122

Q00987 (UniProtKB)

IDA

GO:0001568

Q00987 (UniProtKB)

IEA

GO:0001974

Q00987 (UniProtKB)

IEA

GO:0002027

Q00987 (UniProtKB)

IEA

GO:0002039

Q00987 (UniProtKB)

IPI

GO:0002039

Q00987 (UniProtKB)

IPI

GO:0002039

Q00987 (UniProtKB)

IPI

GO:0003181

Q00987 (UniProtKB)

IEA

GO:0003203

Q00987 (UniProtKB)

IEA

GO:0003281

Q00987 (UniProtKB)

IEA

GO:0003283

Q00987 (UniProtKB)

IEA

GO:0004842

Q00987 (UniProtKB)

IMP

GO:0004842

Q00987 (UniProtKB)

IDA

GO:0004842

Q00987 (UniProtKB)

TAS

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005515

Q00987 (UniProtKB)

IPI

GO:0005634

Q00987 (UniProtKB)

IDA

GO:0005634

Q00987 (UniProtKB)

IMP

GO:0005654

Q00987 (UniProtKB)

IDA

GO:0005654

Q00987 (UniProtKB)

IDA

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005654

Q00987 (UniProtKB)

TAS

GO:0005730

Q00987 (UniProtKB)

IDA

GO:0005730

Q00987 (UniProtKB)

IDA

GO:0005737

Q00987 (UniProtKB)

IMP

GO:0005829

Q00987 (UniProtKB)

TAS

GO:0005829

Q00987 (UniProtKB)

TAS

GO:0005829

Q00987 (UniProtKB)

TAS

GO:0005829

Q00987 (UniProtKB)

TAS

GO:0005829

Q00987 (UniProtKB)

TAS

GO:0005886

Q00987 (UniProtKB)

TAS

GO:0006461

Q00987 (UniProtKB)

IDA

GO:0006461

Q00987 (UniProtKB)

IDA

GO:0006977

Q00987 (UniProtKB)

IMP

GO:0006977

Q00987 (UniProtKB)

TAS

GO:0007089

Q00987 (UniProtKB)

IEA

GO:0008270

Q00987 (UniProtKB)

IDA

GO:0008284

Q00987 (UniProtKB)

TAS

GO:0009743

Q00987 (UniProtKB)

IEA

GO:0010039

Q00987 (UniProtKB)

IEA

GO:0010628

Q00987 (UniProtKB)

IEA

GO:0010955

Q00987 (UniProtKB)

IEA

GO:0016032

Q00987 (UniProtKB)

IEA

GO:0016567

Q00987 (UniProtKB)

IDA

GO:0016567

Q00987 (UniProtKB)

IDA

GO:0016567

Q00987 (UniProtKB)

IDA

GO:0016567

Q00987 (UniProtKB)

IDA

GO:0016874

Q00987 (UniProtKB)

IDA

GO:0016925

Q00987 (UniProtKB)

TAS

GO:0018205

Q00987 (UniProtKB)

IMP

GO:0019789

Q00987 (UniProtKB)

EXP

GO:0019899

Q00987 (UniProtKB)

IPI

GO:0019899

Q00987 (UniProtKB)

IPI

GO:0019899

Q00987 (UniProtKB)

IPI

GO:0019899

Q00987 (UniProtKB)

IPI

GO:0030666

Q00987 (UniProtKB)

TAS

GO:0031625

Q00987 (UniProtKB)

IPI

GO:0031625

Q00987 (UniProtKB)

IPI

GO:0031648

Q00987 (UniProtKB)

IDA

GO:0031648

Q00987 (UniProtKB)

IDA

GO:0032026

Q00987 (UniProtKB)

IEA

GO:0032436

Q00987 (UniProtKB)

IDA

GO:0034504

Q00987 (UniProtKB)

IDA

GO:0042176

Q00987 (UniProtKB)

IDA

GO:0042220

Q00987 (UniProtKB)

IEA

GO:0042493

Q00987 (UniProtKB)

IEA

GO:0042787

Q00987 (UniProtKB)

IDA

GO:0042787

Q00987 (UniProtKB)

IDA

GO:0042787

Q00987 (UniProtKB)

IMP

GO:0042802

Q00987 (UniProtKB)

IPI

GO:0042802

Q00987 (UniProtKB)

IPI

GO:0042802

Q00987 (UniProtKB)

IPI

GO:0042975

Q00987 (UniProtKB)

IEA

GO:0043154

Q00987 (UniProtKB)

IEA

GO:0043234

Q00987 (UniProtKB)

IDA

GO:0043278

Q00987 (UniProtKB)

IEA

GO:0043518

Q00987 (UniProtKB)

IDA

GO:0043518

Q00987 (UniProtKB)

IDA

GO:0045184

Q00987 (UniProtKB)

IDA

GO:0045202

Q00987 (UniProtKB)

IEA

GO:0045472

Q00987 (UniProtKB)

IEA

GO:0045892

Q00987 (UniProtKB)

IDA

GO:0045931

Q00987 (UniProtKB)

IMP

GO:0046677

Q00987 (UniProtKB)

IEP

GO:0046827

Q00987 (UniProtKB)

IEA

GO:0060411

Q00987 (UniProtKB)

IEA

GO:0061630

Q00987 (UniProtKB)

IMP

GO:0061630

Q00987 (UniProtKB)

TAS

GO:0061630

Q00987 (UniProtKB)

TAS

GO:0061630

Q00987 (UniProtKB)

TAS

GO:0070301

Q00987 (UniProtKB)

IEA

GO:0071157

Q00987 (UniProtKB)

IDA

GO:0071236

Q00987 (UniProtKB)

IEA

GO:0071301

Q00987 (UniProtKB)

IEA

GO:0071312

Q00987 (UniProtKB)

IEA

GO:0071363

Q00987 (UniProtKB)

IEA

GO:0071375

Q00987 (UniProtKB)

IEA

GO:0071391

Q00987 (UniProtKB)

IEA

GO:0071456

Q00987 (UniProtKB)

IEP

GO:0071494

Q00987 (UniProtKB)

IEA

GO:0097110

Q00987 (UniProtKB)

IEA

GO:1901796

Q00987 (UniProtKB)

TAS

GO:1901797

Q00987 (UniProtKB)

IDA

GO:0016604

Q00987 (UniProtKB)

IDA

GO:0000122

Q8NDW1 (UniProtKB)

IEA

GO:0016567

Q8NDW1 (UniProtKB)

IEA

GO:0000122

Q96DS5 (UniProtKB)

IEA

GO:0016567

Q96DS5 (UniProtKB)

IEA

GO:0000122

Q9H4C3 (UniProtKB)

IEA

GO:0008270

Q9H4C3 (UniProtKB)

IEA

GO:0016567

Q9H4C3 (UniProtKB)

IEA

GO:0000122

Q9H4C5 (UniProtKB)

IEA

GO:0008270

Q9H4C5 (UniProtKB)

IEA

GO:0016567

Q9H4C5 (UniProtKB)

IEA

可能调控 MDM2基因的相关microRNA：

hsa-miR-26b hsa-miR-504 hsa-miR-605 hsa-miR-125a-3p hsa-miR-125a-5p hsa-miR-125b hsa-miR-142-3p hsa-miR-191 hsa-miR-191* hsa-miR-215

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4120 Ubiquitin mediated proteolysis [PATH:hsa04120]
4068 FoxO signaling pathway [PATH:hsa04068]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4144 Endocytosis [PATH:hsa04144]
4110 Cell cycle [PATH:hsa04110]
4115 p53 signaling pathway [PATH:hsa04115]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
5200 Pathways in cancer [PATH:hsa05200]
5202 Transcriptional misregulation in cancers [PATH:hsa05202]
5206 MicroRNAs in cancer [PATH:hsa05206]
5205 Proteoglycans in cancer [PATH:hsa05205]
5203 Viral carcinogenesis [PATH:hsa05203]
5214 Glioma [PATH:hsa05214]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5218 Melanoma [PATH:hsa05218]
5219 Bladder cancer [PATH:hsa05219]
5215 Prostate cancer [PATH:hsa05215]
5169 Epstein-Barr virus infection [PATH:hsa05169]

名称
Adaptive Immune System
AKT phosphorylates targets in the cytosol
Cell Cycle
Cell Cycle Checkpoints
Cellular responses to stress
Cellular Senescence
Constitutive Signaling by AKT1 E17K in Cancer
DAP12 interactions
DAP12 signaling
Disease
Diseases of signal transduction
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
Fc epsilon receptor (FCERI) signaling
G1/S DNA Damage Checkpoints
GAB1 signalosome
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Immune System
Innate Immune System
Neuronal System
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
NGF signalling via TRKA from the plasma membrane
Oncogene Induced Senescence
Oxidative Stress Induced Senescence
p53-Dependent G1 DNA Damage Response
p53-Dependent G1/S DNA damage checkpoint
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI3K events in ERBB2 signaling
PI3K events in ERBB4 signaling
PI3K/AKT activation
PI3K/AKT Signaling in Cancer
PIP3 activates AKT signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Signal Transduction
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by PDGF
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signalling by NGF
Stabilization of p53
Trafficking of AMPA receptors
Transmission across Chemical Synapses

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Mammary Neoplasms	0.247956418	24	2	BeFree_CTD_human_GAD_LHGDN_RGD
Li-Fraumeni Syndrome	0.133897074	15	2	BeFree_GAD_LHGDN_ORPHANET
melanoma	0.13198705	19	3	BeFree_CTD_human_GAD
Prostatic Neoplasms	0.128001298	6	0	BeFree_CTD_human_GAD_LHGDN
Liposarcoma, Dedifferentiated	0.127600372	28	0	BeFree_ORPHANET
Non-Small Cell Lung Carcinoma	0.126514605	25	0	BeFree_CTD_human
Liposarcoma, well differentiated	0.125157396	19	0	BeFree_ORPHANET
Neoplastic Cell Transformation	0.122367032	2	0	CTD_human_GAD
HIV Infections	0.120814326	4	0	BeFree_CTD_human
Precancerous Conditions	0.120542884	3	0	BeFree_CTD_human

联系方式

山东省济南市章丘区文博路2号齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

更新于2天前

MDM2 (MDM2 proto-oncogene)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

微信公众号