LILRB1 (leukocyte immunoglobulin like receptor B1)

基因基本信息

基因基本信息

symbol:
LILRB1
locus group:
protein-coding gene
location:
19q13.42
gene_family:
CD molecules|Immunoglobulin-like domain containing|Leukocyte immunoglobulin-like receptors
alias symbol:
LIR-1|ILT2|MIR-7|CD85|LIR1|CD85j|PIRB|PIR-B
alias name:
myeloid inhibitory receptor 7|leuc…
entrez id:
10859
ensembl gene id:
ENSG00000104972
ucsc gene id:
uc032iei.2
refseq accession:
NM_001081637
hgnc_id:
HGNC:6605
approved reserved:
2000-01-11

基因染色体位置

基因染色体位置

19q13.42
基因染色体位置图

基因简述

基因简述

LILRB1（白细胞免疫球蛋白样受体B1）属于白细胞免疫球蛋白样受体（LILR）家族，也称为免疫球蛋白样转录物（ILT）家族或CD85家族。这个基因家族主要编码在免疫细胞表面表达的调节性受体，其共同特点是含有免疫球蛋白样结构域，能够识别MHC I类分子并参与免疫调节。LILRB1是一种抑制性受体，主要在髓系细胞（如单核细胞、巨噬细胞和树突状细胞）以及部分淋巴细胞上表达。它的功能是通过与MHC I类分子结合传递抑制信号，从而下调免疫反应，防止过度炎症或自身免疫反应。LILRB1还能识别某些病毒蛋白（如CMV的UL18蛋白），可能被病原体利用逃避免疫监视。突变或异常表达可能影响免疫平衡，例如LILRB1功能丧失可能导致自身免疫疾病风险增加，而过表达则可能抑制抗肿瘤免疫反应，促进肿瘤免疫逃逸。在癌症中，LILRB1的高表达与不良预后相关，因为它能抑制T细胞和NK细胞的活性。降低LILRB1表达可能增强抗肿瘤免疫，但同时也可能增加自身免疫风险。该基因还与妊娠免疫耐受有关，参与母体对胎儿的免疫接受。LILRB1的调控异常还与慢性炎症性疾病、感染性疾病和移植排斥反应等相关。

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

此基因是白细胞免疫球蛋白样受体（LIR）家族，其在染色体区域19q13.4基因簇中发现的成员。所编码的蛋白质属于亚家族B级包含两个或四个细胞外免疫球蛋白结构域，跨膜结构域，并且两个到四个细胞质免疫受体基于酪氨酸的抑制基序（ITIMs）LIR受体。它结合于MHC I类分子上的抗原呈递细胞和转导，抑制一种免疫应答的刺激作用的负信号的受体在免疫细胞中表达。它被认为是控制炎症反应和细胞毒性，以帮助集中的免疫反应并限制自身反应性。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的，2008年7月提供]

OMIM数据库中对LILRB1基因的介绍     Wikipedia数据库中对LILRB1基因的介绍

基因序列

基因序列

LILRB1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

LILRB1基因的碱基突变：           仅显示部分snp
rs272416       rs272416       rs272416       rs272417       rs272417       rs272417       rs272418       rs272418       rs272418       rs272419       rs272419       rs272419       rs272420       rs272420       rs272420       rs272421       rs272421      

基因表达

基因表达

LILRB1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
TRERF1
LILRB1
Repression
18652845

基因本体信息

LILRB1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LILRB1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0016021
A0A087WSV6 (UniProtKB)
IEA
GO:0016021
A0A087WSX8 (UniProtKB)
IEA
GO:0016021
A0A0B4J1W1 (UniProtKB)
IEA
GO:0016021
A0A0G2JLS4 (UniProtKB)
IEA
GO:0016021
A0A0G2JMW5 (UniProtKB)
IEA
GO:0016021
A0A0G2JMX6 (UniProtKB)
IEA
GO:0016021
A0A0G2JN07 (UniProtKB)
IEA
GO:0016021
A0A0G2JNK9 (UniProtKB)
IEA
GO:0016021
A0A0G2JNM2 (UniProtKB)
IEA
GO:0016021
A0A0G2JNQ6 (UniProtKB)
IEA
GO:0016021
A0A0G2JNR3 (UniProtKB)
IEA
GO:0016021
A0A0G2JP64 (UniProtKB)
IEA
GO:0016021
A0A0G2JP80 (UniProtKB)
IEA
GO:0016021
A0A0G2JQ15 (UniProtKB)
IEA
GO:0016021
A0A0G2JQ44 (UniProtKB)
IEA
GO:0016021
A0A0G2JQ46 (UniProtKB)
IEA
GO:0016021
A0A0G2JQS6 (UniProtKB)
IEA
GO:0016021
A0A0G2JS62 (UniProtKB)
IEA
GO:0016021
A0A0G2JS74 (UniProtKB)
IEA
GO:0016021
A8MVE2 (UniProtKB)
IEA
GO:0016021
D9IDM5 (UniProtKB)
IEA
GO:0016021
D9IDM6 (UniProtKB)
IEA
GO:0016021
F6RVM3 (UniProtKB)
IEA
GO:0016021
F6TER3 (UniProtKB)
IEA
GO:0001915
Q8NHL6 (UniProtKB)
IDA
GO:0002230
Q8NHL6 (UniProtKB)
IDA
GO:0002250
Q8NHL6 (UniProtKB)
IEA
GO:0002309
Q8NHL6 (UniProtKB)
IDA
GO:0002740
Q8NHL6 (UniProtKB)
IDA
GO:0002767
Q8NHL6 (UniProtKB)
NAS
GO:0002774
Q8NHL6 (UniProtKB)
IDA
GO:0005576
Q8NHL6 (UniProtKB)
IEA
GO:0005737
Q8NHL6 (UniProtKB)
IDA
GO:0005886
Q8NHL6 (UniProtKB)
TAS
GO:0007165
Q8NHL6 (UniProtKB)
IDA
GO:0008157
Q8NHL6 (UniProtKB)
IPI
GO:0008157
Q8NHL6 (UniProtKB)
IPI
GO:0008157
Q8NHL6 (UniProtKB)
IPI
GO:0008157
Q8NHL6 (UniProtKB)
IPI
GO:0009615
Q8NHL6 (UniProtKB)
IDA
GO:0009615
Q8NHL6 (UniProtKB)
IDA
GO:0009615
Q8NHL6 (UniProtKB)
IDA
GO:0009897
Q8NHL6 (UniProtKB)
IDA
GO:0009897
Q8NHL6 (UniProtKB)
IDA
GO:0009897
Q8NHL6 (UniProtKB)
IDA
GO:0009897
Q8NHL6 (UniProtKB)
IDA
GO:0009897
Q8NHL6 (UniProtKB)
IDA
GO:0009897
Q8NHL6 (UniProtKB)
IDA
GO:0009897
Q8NHL6 (UniProtKB)
IDA
GO:0010628
Q8NHL6 (UniProtKB)
IDA
GO:0014063
Q8NHL6 (UniProtKB)
IDA
GO:0016021
Q8NHL6 (UniProtKB)
IEA
GO:0030107
Q8NHL6 (UniProtKB)
IDA
GO:0030109
Q8NHL6 (UniProtKB)
IDA
GO:0031623
Q8NHL6 (UniProtKB)
TAS
GO:0032393
Q8NHL6 (UniProtKB)
IDA
GO:0032393
Q8NHL6 (UniProtKB)
IDA
GO:0032393
Q8NHL6 (UniProtKB)
IDA
GO:0032393
Q8NHL6 (UniProtKB)
IDA
GO:0032393
Q8NHL6 (UniProtKB)
IDA
GO:0032393
Q8NHL6 (UniProtKB)
IDA
GO:0032393
Q8NHL6 (UniProtKB)
IDA
GO:0032393
Q8NHL6 (UniProtKB)
IDA
GO:0032609
Q8NHL6 (UniProtKB)
IDA
GO:0032689
Q8NHL6 (UniProtKB)
IDA
GO:0032945
Q8NHL6 (UniProtKB)
IDA
GO:0035548
Q8NHL6 (UniProtKB)
IDA
GO:0042130
Q8NHL6 (UniProtKB)
IDA
GO:0042169
Q8NHL6 (UniProtKB)
IDA
GO:0042288
Q8NHL6 (UniProtKB)
IPI
GO:0042288
Q8NHL6 (UniProtKB)
IDA
GO:0042288
Q8NHL6 (UniProtKB)
IPI
GO:0042288
Q8NHL6 (UniProtKB)
IMP
GO:0042288
Q8NHL6 (UniProtKB)
IDA
GO:0042288
Q8NHL6 (UniProtKB)
IPI
GO:0042288
Q8NHL6 (UniProtKB)
IPI
GO:0042288
Q8NHL6 (UniProtKB)
IDA
GO:0042288
Q8NHL6 (UniProtKB)
IMP
GO:0042288
Q8NHL6 (UniProtKB)
IPI
GO:0042288
Q8NHL6 (UniProtKB)
IDA
GO:0042536
Q8NHL6 (UniProtKB)
IDA
GO:0042803
Q8NHL6 (UniProtKB)
IPI
GO:0043065
Q8NHL6 (UniProtKB)
IDA
GO:0045077
Q8NHL6 (UniProtKB)
IDA
GO:0045786
Q8NHL6 (UniProtKB)
IDA
GO:0045806
Q8NHL6 (UniProtKB)
IDA
GO:0045919
Q8NHL6 (UniProtKB)
IDA
GO:0045919
Q8NHL6 (UniProtKB)
IMP
GO:0045944
Q8NHL6 (UniProtKB)
NAS
GO:0045953
Q8NHL6 (UniProtKB)
IDA
GO:0046636
Q8NHL6 (UniProtKB)
IDA
GO:0050776
Q8NHL6 (UniProtKB)
TAS
GO:0051607
Q8NHL6 (UniProtKB)
IDA
GO:0051926
Q8NHL6 (UniProtKB)
IDA
GO:0071222
Q8NHL6 (UniProtKB)
IEP
GO:0072643
Q8NHL6 (UniProtKB)
IDA
GO:0097028
Q8NHL6 (UniProtKB)
IEP
GO:2000669
Q8NHL6 (UniProtKB)
IDA
GO:2001180
Q8NHL6 (UniProtKB)
IDA
GO:2001183
Q8NHL6 (UniProtKB)
IDA
GO:2001186
Q8NHL6 (UniProtKB)
IDA
GO:2001189
Q8NHL6 (UniProtKB)
IDA
GO:2001193
Q8NHL6 (UniProtKB)
IDA
GO:2001199
Q8NHL6 (UniProtKB)
IMP
GO:2001202
Q8NHL6 (UniProtKB)
IDA
GO:2001205
Q8NHL6 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 LILRB1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Peripheral Neuropathy 0.12 1 0 CTD_human
Rheumatoid Arthritis 0.005362824 1 0 BeFree_GAD_LHGDN
Lupus Erythematosus, Systemic 0.003538676 4 0 BeFree_LHGDN
Dermatomyositis 0.002995792 2 0 BeFree_LHGDN
Neoplasm Metastasis 0.002985861 11 0 BeFree
Breast Carcinoma 0.002985861 11 0 BeFree
Malignant neoplasm of breast 0.002985861 11 0 BeFree
Polymyositis 0.00272435 1 0 LHGDN
Inclusion Body Myositis (disorder) 0.00272435 1 0 LHGDN
Influenza 0.00272435 1 0 LHGDN

基因相关服务

基因相关服务

联系方式

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