FASLG (Fas ligand)

基因基本信息

基因基本信息

symbol:
FASLG
locus group:
protein-coding gene
location:
1q24.3
gene_family:
CD molecules|Endogenous ligands|Tumor necrosis factor (ligand) superfamily
alias symbol:
FasL|CD178
alias name:
None
entrez id:
356
ensembl gene id:
ENSG00000117560
ucsc gene id:
uc001gis.4
refseq accession:
NM_000639
hgnc_id:
HGNC:11936
approved reserved:
1994-12-09

基因染色体位置

基因染色体位置

1q24.3
基因染色体位置图

基因简述

基因简述

FASLG（Fas ligand，也称为CD95L或TNFSF6）是肿瘤坏死因子（TNF）超家族成员之一，属于II型跨膜蛋白，其基因位于人类1号染色体（1q23）。FASLG的主要功能是通过与受体FAS（CD95）结合，激活细胞凋亡（程序性细胞死亡）信号通路，在免疫调节、免疫耐受和清除异常细胞（如病毒感染细胞或肿瘤细胞）中起关键作用。FASLG主要在活化的T细胞和自然杀伤（NK）细胞表面表达，也可通过金属蛋白酶切割形成可溶性形式。FASLG与FAS结合后，触发死亡诱导信号复合体（DISC）形成，激活半胱天冬酶（caspase）级联反应，最终导致细胞凋亡。FASLG基因突变可能导致功能丧失，与自身免疫性淋巴增生综合征（ALPS）相关，表现为淋巴细胞异常积累和自身免疫疾病；而过度表达可能引起组织损伤，如肝炎或移植物抗宿主病（GVHD）。FASLG属于TNF超家族（TNFSF），该家族成员均为细胞因子，通过三聚体结构与相应受体结合，参与炎症、免疫和凋亡调控。FASLG表达异常（过高或过低）均可能破坏免疫稳态：过表达会增强细胞毒性，导致健康组织损伤；而低表达可能削弱免疫监视功能，增加肿瘤或感染风险。此外，FASLG还参与免疫豁免部位（如眼睛和睾丸）的免疫特权维持。某些病毒（如HIV）可下调FASLG表达以逃避免疫清除，而肿瘤细胞也可能通过FASLG/FAS通路失调抵抗凋亡。

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

该基因是肿瘤坏死因子超家族的成员。所编码的跨膜蛋白的主要功能是细胞凋亡的通过结合到FAS触发的诱导。所述FAS / FASLG信号通路是免疫系统的调节，包括T细胞和细胞毒性T淋巴细胞诱导的细胞死亡的活化诱导的细胞死亡（AICD）是必不可少的。还已牵涉于多种癌症的进展。在这个基因的缺陷可能与全身性红斑狼疮（SLE）的一些情况下。可变剪接转录物变体已有描述。 [由RefSeq的，2014年11月提供]

OMIM数据库中对FASLG基因的介绍     Wikipedia数据库中对FASLG基因的介绍

基因序列

基因序列

FASLG基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

FASLG基因的碱基突变：           仅显示部分snp
rs17475       rs17476       rs749154       rs749155       rs763110       rs929087       rs2021837       rs2022556       rs2639653       rs2639654       rs2859248       rs3820654       rs5030772       rs6690331       rs6700734       rs9787248       rs9787393      

基因表达

基因表达

FASLG基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TTGCCTTGGTAGGATTGGG
60
CATCTGGCTGGTAGACTCTC
59
TTTAACAGGCAAGTCCAACTC
59
CTTCACTCCAGAAAGCAGG
58
CCACCTACAGAAGGAGCTG
60
TTGGACTTGCCTGTTAAATGG
59
TTTAACAGGCAAGTCCAACTC
59
TTCACTCCAGAAAGCAGGA
59
CACCTACAGAAGGAGCTGG
60
TTGGACTTGCCTGTTAAATGG
59
GTTGCCTTGGTAGGATTGG
59
ATCTGGCTGGTAGACTCTC
58
GAGAAGCAAATAGGCCACC
59
GACCTTGAGTTGGACTTGC
59
ATTTAACAGGCAAGTCCAACTC
59
TCACTCCAGAAAGCAGGAC
59
CTACAGAAGGAGCTGGCAG
60
TTGGACTTGCCTGTTAAATGG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ATF2
FASLG
Unknown
19670268; 9710625
CEBPB
FASLG
Unknown
12496392
CIITA
FASLG
Unknown
14563113
CREM
FASLG
Repression
11754361
EGR1
FASLG
Unknown
14563113
EGR2
FASLG
Repression
19651900
FOXO3
FASLG
Activation
11756562
IRF1
FASLG
Unknown
14563113
JUN
FASLG
Unknown
14563113; 19670268; 9710625
MAX
FASLG
Unknown
10734130

基因本体信息

FASLG基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

FASLG基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000122
P48023 (UniProtKB)
IDA
GO:0005102
P48023 (UniProtKB)
TAS
GO:0005123
P48023 (UniProtKB)
IEA
GO:0005125
P48023 (UniProtKB)
IEA
GO:0005164
P48023 (UniProtKB)
IEA
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005515
P48023 (UniProtKB)
IPI
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005576
P48023 (UniProtKB)
TAS
GO:0005615
P48023 (UniProtKB)
IDA
GO:0005634
P48023 (UniProtKB)
IDA
GO:0005886
P48023 (UniProtKB)
IDA
GO:0005887
P48023 (UniProtKB)
TAS
GO:0005901
P48023 (UniProtKB)
IEA
GO:0006351
P48023 (UniProtKB)
IEA
GO:0006915
P48023 (UniProtKB)
TAS
GO:0006919
P48023 (UniProtKB)
IMP
GO:0006919
P48023 (UniProtKB)
IGI
GO:0006919
P48023 (UniProtKB)
TAS
GO:0006925
P48023 (UniProtKB)
IEA
GO:0006955
P48023 (UniProtKB)
IEA
GO:0007165
P48023 (UniProtKB)
TAS
GO:0007267
P48023 (UniProtKB)
TAS
GO:0008284
P48023 (UniProtKB)
IEA
GO:0008625
P48023 (UniProtKB)
IDA
GO:0009897
P48023 (UniProtKB)
IEA
GO:0016525
P48023 (UniProtKB)
IDA
GO:0030644
P48023 (UniProtKB)
IEA
GO:0032496
P48023 (UniProtKB)
IEA
GO:0043065
P48023 (UniProtKB)
IDA
GO:0043065
P48023 (UniProtKB)
IDA
GO:0043123
P48023 (UniProtKB)
IEP
GO:0043202
P48023 (UniProtKB)
IEA
GO:0043525
P48023 (UniProtKB)
IEA
GO:0045742
P48023 (UniProtKB)
IEA
GO:0046666
P48023 (UniProtKB)
IEA
GO:0048388
P48023 (UniProtKB)
IEA
GO:0048471
P48023 (UniProtKB)
IEA
GO:0060205
P48023 (UniProtKB)
IEA
GO:0070062
P48023 (UniProtKB)
IDA
GO:0070231
P48023 (UniProtKB)
IDA
GO:0070266
P48023 (UniProtKB)
IDA
GO:0070848
P48023 (UniProtKB)
IEA
GO:0097190
P48023 (UniProtKB)
IDA
GO:0097190
P48023 (UniProtKB)
TAS
GO:0097190
P48023 (UniProtKB)
TAS
GO:0097191
P48023 (UniProtKB)
IDA
GO:0097296
P48023 (UniProtKB)
TAS
GO:0097527
P48023 (UniProtKB)
IDA
GO:1902041
P48023 (UniProtKB)
TAS
GO:1902042
P48023 (UniProtKB)
TAS
GO:1902042
P48023 (UniProtKB)
TAS
GO:2000353
P48023 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 FASLG基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Autoimmune Lymphoproliferative Syndrome 0.322171535 8 2 BeFree_CLINVAR_MGD_ORPHANET
Diabetes Mellitus, Insulin-Dependent 0.160542884 3 0 BeFree_MGD_RGD
Lupus Erythematosus, Systemic 0.137631247 14 1 BeFree_CTD_human_GAD_LHGDN
melanoma 0.136902798 11 0 BeFree_CTD_human_GAD_LHGDN
Rheumatoid Arthritis 0.123810118 6 2 BeFree_CTD_human_LHGDN
Cardiomyopathies 0.12272435 2 0 CTD_human_LHGDN
Atherosclerosis 0.12272435 2 0 CTD_human_LHGDN
Non-Small Cell Lung Carcinoma 0.121085767 4 1 BeFree_CTD_human
Hepatitis 0.120271442 2 0 BeFree_CTD_human
Autoimmune Lymphoproliferative Syndrome, Type IB 0.12 0 1 CLINVAR

基因相关服务

基因相关服务

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