Transcription profiling of CD4+ T lymphocytes in response to an irradiation dose of 1 Gy.radiation
ID:
状态:
发布时间Dec. 31, 2005
, 更新时间 May 2, 2014
, 提交时间 April 27, 2005,
物种:
Homo sapiens
摘要:
Differences in radiosensitivity existing among cells which constitute the lymphocyte population have been known for a long time, although the molecular basis of this differential radiation sensitivity remains unclear. In an attempt to get more insight into the molecular mechanisms leading to radiation effects, we used microarray analysis to study transcriptional changes in CD4+ T lymphocytes to an irradiation dose of 1 Gy. The contribution of the cell type to the radiation response of CD4+ lymphocytes was deduced by comparing our results with a gene expression profile observed in Peripheral Blood Lymphocytes published by other groups (Amundson, 2000; Kang, 2003, Jen, 2003).