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题目:: Temporal effects of intermittent- and sustained hypoxia on gene expression patterns in rat lungs
ID:
状态:: 发布时间Dec. 17, 2008 , 更新时间 March 27, 2012 , 提交时间 Aug. 5, 2007,
物种:: Rattus norvegicus
摘要:: Time-course gene expression profiles were obtained from lung tissues of the rats treated with room air, intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days using CodeLink microarrays. Using a systems biology approach, we observed that two different mechanisms are involved in the lung responses to IH and SH: IH leads to increased G-protein coupled signaling-, ion transport-, neuronal- and steroid hormone receptor activities; whereas SH causes increased blood vessel morphogenesis and immune responses. Our results provide insight into molecular mechanisms underlying IH and SH. Keywords: gene expression array-based, count rats were treated with intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days; rats treated with room air were used as controls; gene expression profiles were obtained from these rats
实验种类:: transcription profiling by array
样本量:: 42
实验设计:
: 无设计数据
数据号:: E-GEOD-8705, GSE8705
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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