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题目:: Transcription profiling of human monocyte derived macrophages response to IL-1 and IL-6
ID:
状态:: 发布时间June 16, 2008 , 更新时间 June 10, 2011 , 提交时间 July 18, 2007,
物种:: Homo sapiens
摘要:: Using whole-genome Affymetrix microarrays (HG-U133A), we characterized the transcriptome profile of cultured human macrophages stimulated for 4 h with interleukin 1 (IL-1) or interleukin 6 (IL-6). We found that, in distinction to liver cells, IL-1 is much more potent than IL-6 in modifying macrophage gene expression, although considerable heterogeneity in response of macrophages deriving from individual blood donors was observed. The obtained results permitted to identify a large number of cytokine-responsive genes. coding for proteins of unknown function that are now being studied in our laboratory. They may represent novel targets in the anti-inflammatory therapy. Experiment Overall Design: Analysis of the transcriptome of human monocyte-derived macrophages stimulated in vitro by low doses of IL-1 or IL-6.
实验种类:: transcription profiling by array
样本量:: 15
实验设计:
: 无设计数据
数据号:: E-GEOD-8515, GSE8515
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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