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题目:: Transcription profiling of human hypothalamic hamartomas (HH) obtained from patients with or without precocious puberty (CPP)
ID:
状态:: 发布时间June 15, 2008 , 更新时间 March 27, 2012 , 提交时间 Feb. 27, 2007,
物种:: Homo sapiens
摘要:: Hypothalamic hamartomas (HHs) are congenital lesions of the neuroendocrine brain composed of neurons and astroglia. Frequently, HHs are associated with central precocious puberty (CPP) and/or gelastic seizures. Because HHs might express genes similar to those required for the initiation of normal puberty we used cDNA arrays to compare the gene expression profile of a HH associated with CPP with three HHs not accompanied by sexual precocity. Our aim was to identify genes whose expression may be selectively altered in the HH with CPP and hence, involved in the onset of puberty. Experiment Overall Design: Affymetrix arrays were used to detect global changes in gene expression. The results of this analysis were confirmed by semi-quantitative PCR.
实验种类:: transcription profiling by array
样本量:: 4
实验设计:
: 无设计数据
数据号:: E-GEOD-7142, GSE7142
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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