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题目:: Transcription profiling of human CEM-C1 cells treate with rapamycin for 3 hours
ID:
状态:: 发布时间June 14, 2008 , 更新时间 May 15, 2013 , 提交时间 Sept. 13, 2006,
物种:: Homo sapiens
摘要:: Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression signature of glucocorticoid (GC) sensitivity/resistance in Acute Lymphoblastic Leukemia (ALL) cells. The screen indicated the mTOR inhibitor rapamycin profile matched the signature of GC-sensitivity. We thus tested the hypothesis that rapamycin would induce GC sensitivity in lymphoid malignancy cells, and found that it sensitized cells to glucocorticoid induced apoptosis via modulation of antiapoptotic MCL1. These data indicate that MCL1 is an important regulator of GC-induced apoptosis, and that the combination of rapamycin and glucocorticoids has potential utility in ALL. Furthermore this approach represents a novel strategy for identification of promising combination therapies for cancer. Experiment Overall Design: CEM-C1 cells were treated with 10 nM rapamycin for 3 hours and compared to DMSO treated cells
实验种类:: transcription profiling by array
样本量:: 6
实验设计:
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数据号:: E-GEOD-5822, GSE5822
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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