Heterogeneity in MYC-Induced Mammary Tumors Determines Outcomes Following Loss of Myc Activity
ID:
状态:
发布时间July 8, 2010
, 更新时间 May 1, 2014
, 提交时间 June 16, 2010,
物种:
Mus musculus
摘要:
We used microarrays to compare gene expression profiles between mouse mammary tumors initiated by Myc to those that have escaped Myc oncogene dependence. We collected tumor biopsies of Myc-initiated tumors and samples of tumors that persisted or recurred after Myc withdrawal. RNA was extracted from these tumors and hybridized to microarrays.