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题目:: The growth factor environment defines distinct pluripotent ground states in novel blastocyst derived stem cells
ID:
状态:: 发布时间May 17, 2010 , 更新时间 March 27, 2012 , 提交时间 Aug. 20, 2008,
物种:: Mus musculus
摘要:: Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic stem cell lines (ES cells), as well as the post-implantation epiblast, which gives rise to epiblast stem cell lines (EpiSCs). Remarkably, ES cells and EpiSCs display profound differences in the combination of growth factors that maintain their pluripotent state. Molecular and functional differences between these two stem cell types demonstrate that the tissue of origin and/or the growth factor milieu may be important determinants of the stem cell identity. We explored how developmental stage of the tissue of origin and culture growth factor conditions affect the stem cell pluripotent state. Our findings reveal that novel stem cell lines can be generated from blastocyst embryos with unique functional and molecular properties. We demonstrate that the culture growth factor environment and cell-cell interaction play a critical role in defining several unique and stable stem cell ground states. Keywords: Clonal analysis of FAB-SC gene expression Cell type characterization - 3 separate single cell clones
实验种类:: transcription profiling by array
样本量:: 3
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数据号:: E-GEOD-12519, GSE12519
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